93184-10-2

Basic information

• Product Name: MONO-2-O-(P-TOLUENESULFONYL)-ALPHA-CYCLODEXTRIN
• Synonyms: MONO-2-O-(P-TOLUENESULFONYL)-ALPHA-CYCLODEXTRIN;Mono-2-O-(p-toluenesulfonyl)-αMono-2-O-(P-Toluenesulfonyl)-Alpha-Cyclodextrin, 98.0+%(LC)
• CAS NO: 93184-10-2
• Molecular Formula: C₄₃H₆₆O₃₂S
• Molecular Weight: 1155.08
• Product Categories: Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry
• Mol File: 93184-10-2.mol

Chemical Properties

• Melting Point: 176 °C
• Appearance: /
• Refractive Index: 116 ° (C=4, DMSO)
• CAS DataBase Reference: MONO-2-O-(P-TOLUENESULFONYL)-ALPHA-CYCLODEXTRIN(CAS DataBase Reference)
• NIST Chemistry Reference: MONO-2-O-(P-TOLUENESULFONYL)-ALPHA-CYCLODEXTRIN(93184-10-2)
• EPA Substance Registry System: MONO-2-O-(P-TOLUENESULFONYL)-ALPHA-CYCLODEXTRIN(93184-10-2)

Safety Data

• Hazardous Substances Data: 93184-10-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
MONO-2-O-(P-TOLUENESULFONYL)-ALPHA-CYCLODEXTRIN is used as a key component in the synthesis of organotellurium-bridged cyclodextrin dimers for their artificial glutathione peroxidase activities. These dimers have potential applications in the development of novel therapeutic agents and drug delivery systems, contributing to advancements in medicine and healthcare.
Used in Chemical Research:
In the field of chemical research, MONO-2-O-(P-TOLUENESULFONYL)-ALPHA-CYCLODEXTRIN serves as a valuable tool for the characterization and study of organotellurium-bridged cyclodextrin dimers. This helps researchers gain insights into their properties, behavior, and potential applications, further expanding the knowledge base in chemistry and related disciplines.

Upstream product

• 3899-90-9 3-nitrophenyl 4-methylbenzenesulfonate 
• 10016-20-3 alpha cyclodextrin 
• 98-59-9 p-toluenesulfonyl chloride 
• 2232-08-8 N-tosylimidazole 

Relevant articles and documents

Efficient regioselective functionalizations of cyclodextrins carried out under microwaves or power ultrasound

Regioselective syntheses of differently functionalized cyclodextrins (CDs) were efficiently carried out under ultrasound or microwave irradiation. 6I-Deoxy-6I-thio-β-CD, 6I-deoxy-6I-formyl-β-CD, and 6A,6D-dideoxy-6A,6D-dithio-β-CD were prepared under microwave irradiation. A new rapid and efficient ultrasound-assisted protocol is described for the synthesis of 3I-azido-3I-deoxy-α, -β, and -γ-CD by selective tosylation followed by azide substitution.

REGIOSELECTIVE SULFONATION OF A SECONDARY HYDROXYL GROUP OF CYCLODEXTRINS

A new and convenient procedure has been developed for the regioselective tosylation of a C-2 hydroxyl group of cyclodextrins via cyclic tin intermediate.

MONOTOSYLATED α-AND β-CYCLODEXTRINS PREPARED IN AN ALKALINE AQUEOUS SOLUTION

In order to establish the tosylated positions of α- and β-cyclodextrins, 13C-nmr spectra for the monotosyl-derivatives prepared in an alkaline aqueous solution were examined and determined to be in the 6-position of one glucose unit for β-cyclodextrin and

CONVENIENT PREPARATION AND EFFECTIVE SEPARATION OF THE C-2 AND C-3 TOSYLATES OF α-CYCLODEXTRIN

Secondary tosylates of α-cyclodextrin were conveniently prepared by the reaction of the cyclodextrin with tosyl chloride in alkaline water where pH of the mixture should be allowed to decrease as the proceeding of reaction, and were effectivelly separated by reversed-phase column chromatography.