932-33-2

Basic information

• Product Name: Benzene, 1-chloro-2-nitroso-
• Synonyms: Benzene, 1-chloro-2-nitroso-
• CAS NO: 932-33-2
• Molecular Formula: C₆H₄ClNO
• Molecular Weight: 141.55506
• Mol File: 932-33-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 56-57 °C
• Boiling Point: 224.7±23.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Benzene, 1-chloro-2-nitroso-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-2-nitroso-(932-33-2)
• EPA Substance Registry System: Benzene, 1-chloro-2-nitroso-(932-33-2)

Safety Data

• Hazardous Substances Data: 932-33-2(Hazardous Substances Data)

Usage

General Description

Benzene, 1-chloro-2-nitroso-, is a chemical compound with the molecular formula C6H5ClNO. It is a nitroso compound and is used mainly as an intermediate in the production of dyes, pharmaceuticals, and other organic compounds. 1-chloro-2-nitroso-benzene is a pale yellow solid and is considered to be mildly toxic. It is used in the production of pesticides, as well as in the synthesis of other chemicals and pharmaceuticals. Additionally, the compound has been identified as a potential mutagen and may pose health risks to those exposed to it. As such, proper safety protocols must be followed when working with this chemical.

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 142-04-1 aniline hydrochloride 
• 10468-16-3 2-chloro-N-hydroxybenzenamine 
• 95-51-2 o-chloroaniline 
• 17315-42-3 (CH₃)3SnC₆H₄-o-Cl 

Downstream Products

• 13556-84-8 2,2'-dichloroazoxybenzene 
• 13556-84-8 2,2'-dichloroazoxybenzene 
• 3296-07-9 1-azido-2-chlorobenzene 
• 52566-59-3 2-(2-chloro-N-hydroxy-anilino)-4H-benzo[1,4]oxazin-3-one 
• 2285-74-7 N-<2-Chlor-phenyl>-N'-fluordiimid-N-oxid 
• 263-06-9 6H,12H-Dibenzo<1,5>dithiocin 
• 108288-69-3 2-(2-Chlorphenyl)-4H-3,1,2-benzoxathiazin 
• 1430850-84-2 C₁₅H₁₁ClN₂O₂ 
• 1188929-99-8 2-chloro-N-(2,4,6-trimethylphenyl)aniline 
• 1260117-42-7 (S)-2-(2-chlorophenylaminoxy)-1-phenylpropan-1-one 
• 817553-63-2 bis(acetato)bis[2-(3-chloro-2-nitrosophenyl)-(2-chlorophenyl)amide]dipalladium 
• 207797-61-3 (η(5)-cyclopentadienyl)[1-9a-η(6)-9-fluorenone-(2'-chloro)-anil]iron(II) hexafluorophosphate 
• 95-51-2 o-chloroaniline 
• 7334-33-0 2,2'-dichloroazobenzene 

Relevant articles and documents

Transketolase Catalyzed Synthesis of N-Aryl Hydroxamic Acids

Hydroxamic acids are metal-chelating compounds that show important biological activity including anti-tumor effects. We have recently engineered the transketolase from Geobacillus stearothermopilus (TKgst) to convert benzaldehyde as a non-natur

Nitrosobenzene-Enabled Chiral Phosphoric Acid Catalyzed Enantioselective Construction of Atropisomeric N-Arylbenzimidazoles

Described herein is an imidazole ring formation strategy for the synthesis of axially chiral N-arylbenzimidazoles by means of chiral phosphoric acid catalysis. Two sets of conditions were developed to transform two classes of 2-naphthylamine derivatives into structurally diverse N-arylbenzimidazole atropisomers with excellent chemo- and regioselectivity as well as high levels of enantiocontrol. It is worth reflecting on the unique roles played by the nitroso group in this domino reaction. It functions as a linchpin by first offering an electrophilic site (N) for the initial C?N bond formation while the resulting amine performs the nucleophilic addition to form the second C?N bond. Additionally, it could facilitate the final oxidative aromatization as an oxidant. The atropisomeric products could be conveniently elaborated to a series of axially chiral derivatives, enabling the exploitation of N-arylbenzimidazoles for their potential utilities in asymmetric catalysis.

Enantioselective Oxidative Coupling of β-Ketocarbonyls and Anilines by Joint Chiral Primary Amine and Selenium Catalysis

An enantioselective primary amine-catalyzed total N-selective nitroso aldol reaction (N-NA) was achieved through the oxidation of primary aromatic amines to the corresponding nitrosoarenes catalyzed by selenium reagents and 30% H2O2. This protocol provides a facile and highly efficient access to α-hydroxyamino carbonyls bearing chiral quaternary centers under exceedingly mild and green reaction conditions with high chemo-and enantiocontrol.