932034-85-0Relevant articles and documents
Potent, selective MCH-1 receptor antagonists
Erickson, Shawn D.,Banner, Bruce,Berthel, Steven,Conde-Knape, Karin,Falcioni, Fiorenza,Hakimi, Irina,Hennessy, Bernard,Kester, Robert F.,Kim, Kyungjin,Ma, Chun,McComas, Warren,Mennona, Francis,Mischke, Steven,Orzechowski, Lucy,Qian, Yimin,Salari, Hamid,Tengi, John,Thakkar, Kshitij,Taub, Rebecca,Tilley, Jefferson W.,Wang, Hong
, p. 1402 - 1406 (2008)
This paper describes the lead optimization of a new series of potent, selective, orally bioavailable, brain-penetrant MCH-1 receptor antagonists. A major focus of the work was to achieve a selectivity profile appropriate for in vivo efficacy studies and safety.
MCH receptor antagonists
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Page/Page column 5-6, (2008/06/13)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.