932040-48-7 Usage
Molecular weight
295.35 g/mol The relative molecular mass of the compound based on the atomic weights of its constituent elements.
Tert-butyl group
(CH3)3CA bulky, non-reactive alkyl group that can protect other functional groups in the molecule from unwanted reactions.
Ethyl group
C2H5A two-carbon alkyl group that adds flexibility to the molecule and can influence its biological activity.
Pyrrolidine ring
C4H8N A five-membered nitrogen-containing heterocyclic ring that is a common structural element in many pharmacologically active compounds.
(2R) configuration
The stereochemistry of the compound, indicating that the hydroxyl group is on the right side of the molecule when viewed from the 2-position.
5-hydroxyl group
-OH at the 5-position A polar, hydrophilic functional group that can participate in hydrogen bonding and may influence the compound's solubility and biological activity.
1,2-dicarboxylate groups
Two -COOgroups at the 1and 2-positions These groups can chelate metal ions and may contribute to the compound's biological activity or serve as functional handles for further chemical modifications.
Potential biological activity
The presence of the pyrrolidine ring and other functional groups suggests that the compound may have potential as a drug or prodrug, but further research and testing are needed to determine its specific biological activity and potential applications.
Use as a building block in pharmaceutical synthesis
Due to its potential biological activity, the compound is often used as a starting material or intermediate in the synthesis of various pharmaceutical compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 932040-48-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,2,0,4 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 932040-48:
(8*9)+(7*3)+(6*2)+(5*0)+(4*4)+(3*0)+(2*4)+(1*8)=137
137 % 10 = 7
So 932040-48-7 is a valid CAS Registry Number.
932040-48-7Relevant articles and documents
Synthesis and biological evaluation of all eight stereoisomers of DPP-IV inhibitor saxagliptin
Dong, Jizhe,Gong, Yanchun,Liu, Jun,Chen, Xiangfeng,Wen, Xiaoan,Sun, Hongbin
, p. 1383 - 1393 (2014/03/21)
All eight stereoisomers of saxagliptin have been synthesized and evaluated for their inhibitory activity against DPP-IV. It was unambiguously confirmed that the configuration of saxagliptin was critical to potent inhibition of DPP-IV. Docking study was performed to elucidate the configuration-activity relationship of saxagliptin stereoisomers. Tyr662 and Tyr470 have been suggested as the key residues of DPP-IV interacting with the inhibitors. This work provides valuable information for further inhibitor design against DPP-IV.
