93213-89-9

Upstream product

• 91021-14-6 5-fluoro-3-(2-oxo-2-phenylethylidene)indolin-2-one 
• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 70-11-1 α-bromoacetophenone 

Relevant academic research and scientific papers

Facile synthesis of functionalized spiro[indoline-3,2'-oxiran]-2-ones by Darzens reaction

A series of functionalized spiro[indoline-3,2'-oxiran]-2-ones was efficiently synthesized by Darzens reaction of phenacyl bromides with isatins both with N-alkyl groups and without N-substituent in the presence of potassium carbonate as a base catalyst. When two equivalents phenacyl bromides were used in the reaction, the N-substitution reaction of isatin also finished with the formation of spiro-oxirane-oxindoles.

Studies in Spiroheterocycles. Part V. Synthesis of New Fluorinated Spiro-2(1H)-ones

Reinvestigation of the reaction of 3-aroylmethyleneindol-2-ones with hydrogen peroxide has revealed that a 1:1 isomeric mixture of spiro-2(1H)-ones is formed.The structure of the two isomers have been confirmed by their ir, pmr and mass spectral studies.Mass fragmentation patterns of these compounds are discussed.