93214-74-5

Usage

Molecular weight

238.21 g/mol This is the mass of one mole of the compound, measured in grams.

Class

Pyrazoles This is a group of chemical compounds that share a similar structure and properties.

Derivative of pyrazol-5-ol

This means that the compound is a modified version of the parent compound pyrazol-5-ol.

Contains a nitrophenyl group

This is a functional group that consists of a phenyl ring (a ring of six carbon atoms with alternating single and double bonds) with a nitro group (-NO2) attached.

Potential applications

Pharmaceutical and Agrochemical industries This means that the compound has potential uses in the production of drugs and chemicals used in agriculture.

Pharmacological properties

Anti-inflammatory and antitumor These are the potential therapeutic effects of the compound, which have been studied in research.

Interesting target for further research and development

This means that the compound has potential for further study and development in various fields due to its unique chemical structure and properties.

Upstream product

• 4023-82-9 4-nitrobenzoylacetone 
• 93214-70-1 3-Methyl-5-(4-nitro-phenyl)-pyrazolidine-3,5-diol 

Downstream Products

• 94487-88-4 3-methyl-5-(4-nitrophenyl)pyrazole 

Relevant academic research and scientific papers

5-Hydroxy-2-pyrazolines and some of their 1-substituted analogs

The use of 1,3-dicarbonyl compounds containing strong electron-withdrawing substituents (perfluoroalkyl, 4-nitrophenyl) at one of the carbonyl groups in reaction with hydrazine or its monosubstituted derivatives (4-nitro- and 2,4-dinitrophenylhydrazines) leads to the formation of stable intermediates for the synthesis of pyrazoles (5-hydroxy-2-pyrazolines) or their linear tautomers (hydrazones).

5-Hydroxy-4,5-Dihydropyrazoles

The use of β-diketones with strong electron-withdrawing substituents in reaction with hydrazine and its monosubstituted derivatives leads to the stable intermediates of pyrazole synthesis - 5-hydroxy-4,5-dihydropyrazoles or their open chain isomers.

INVESTIGATION OF THE MECHANISMS OF FORMATION OF HETEROCYCLES BY NMR SPECTROSCOPY. III. THE EFFECT OF ELECTRONIC FACTORS ON THE KINETICS OF THE DEHYDRATION OF DIHYDROXYPYRAZOLIDINES AND HYDROXYPYRAZOLINES- THE INTERMEDIATES IN THE REACTION OF HYDRAZINE WITH 1,3-DIKETONES

The rate constants for the dehydration of the dihydroxypyrazolidine and hydroxypyrazoline intermediates in the reaction of hydrazine with substituted benzoylacetones p-XC6H4COCH2COCH3 (X= CH3O, CH3, H, Cl, NO2) in methanol were determined by NMR spectroscopy using the stopped-flow technique.Increase in the electronegativity of the substituent leads, on the one hand, to an increase in the contribution from the reaction path involving the formation of the tautomeric pyrazoles with the participation of 3-methyl-5-(p-XC6H4)-5-hydroxypyrazoline and, on the other hand, to an increase in the rate of its conversion into the corresponding pyrazole.Analysis of the relationships between the dehydration rates and the Hammett ? constants confirms a reaction mechanism with the participation of the cyclic dihydroxypyrazolidine intermediate.