93233-36-4Relevant academic research and scientific papers
An efficient and general method for the reformatsky-type reaction of chlorodifluoromethyl ketones with carbonyl compounds giving α,α-difluoro-β-hydroxy ketones1)
Kuroboshi,Ishihara
, p. 428 - 437 (2007/10/02)
Chlorodifluoromethyl ketones CF2ClCOR, where R is an alkyl, aryl, and l-alkynyl group, underwent the Reformatsky-type aldol reaction with a wide variety of aldehydes or ketones in the presence of acid-washed zinc dust and copper(I) chloride or
ZINC-COPPER(I) CHLORIDE OR -SILVER(I) ACETATE PROMOTED ALDOL REACTION OF CHLORODIFLUOROMETHYL KETONES WITH CARBONYL COMPOUNDS. A GENERAL AND EFFECTIVE ROUTE TO α,α-DIFLUORO-β-HYDROXY KETONES
Kuroboshi, Manabu,Ishihara, Takashi
, p. 6481 - 6484 (2007/10/02)
Chlorodifluoromethyl ketones efficiently underwent the aldol reaction with a variety of aldehydes or ketones in the presence of zinc, a catalytic amount of copper(I) chloride or silver(I) acetate, and molecular sieves to give the corresponding α,α-difluor
NEW LOW-VALENT TITANIUM CATALYZED REACTION OF CHLORODIFLUOROMETHYL KETONES LEADING TO α,α-DIFLUORINATED β-HYDROXY KETONES
Ishihara, Takashi,Yamanaka, Tohru,Ando, Teiichi
, p. 1165 - 1168 (2007/10/02)
Various chlorodifluoromethyl ketones underwent the aldol-type reaction with aldehydes or ketones by the action of titanium tetrachloride and zinc reagent in tetrahydrofuran at room temperature to give moderate to good yields of α,α-difluorinated β-hydroxy
