932374-64-6

Basic information

• Product Name: N-(4,5-dichloro-2-nitrophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine
• Synonyms: N-(4,5-dichloro-2-nitrophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine
• CAS NO: 932374-64-6
• Molecular Weight: 374.267
• Mol File: 932374-64-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4,5-dichloro-2-nitrophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4,5-dichloro-2-nitrophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine(932374-64-6)
• EPA Substance Registry System: N-(4,5-dichloro-2-nitrophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine(932374-64-6)

Safety Data

• Hazardous Substances Data: 932374-64-6(Hazardous Substances Data)

Upstream product

• 2339-78-8 1,2-dichloro-4-fluoro-5-nitrobenzene 

Downstream Products

• 932374-65-7 N-(4,5-dichloro-2-aminophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine 

Relevant articles and documents

COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of formula (I) and salts and solvates are provided: In a first aspect therefore, the invention provides a compound of formula (I) or a salt or solvate thereof: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C 1-6 alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.