932406-25-2

Upstream product

• 31063-90-8 Boc-Tyr(Bn)-Ser-OMe 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 16652-64-5 O-benzyl-S-tyrosine 

Downstream Products

• 932406-26-3 (S)-methyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxy-carbonylamino)propanethioamido)-3-hydroxypropanoate 
• 932406-29-6 (S,E)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-(2-methyl-3-oxo-prop-1-enyl)thiazol-2-yl)ethylcarbamate 
• 932406-28-5 (S)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-formylthiazol-2-yl)ethylcarbamate 
• 932406-27-4 (S)-methyl 2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxy-carbonylamino)ethyl)thiazole-4-carboxylate 

Relevant academic research and scientific papers

Unified azoline and azole syntheses by optimized aza-wittig chemistry

Intramolecular aza-Wittig ring closures were applied to synthesize thiazolines, oxazolines, and imidazolines from β-azido thioester, ester, and amide precursors. The cyclization precursors were obtained from amino acid derivatives. Optimized conditions fo

Preparation and biological evaluation of key fragments and open analogs of scleritodermin A

The synthesis of key fragments of scleritodermin A, their assembly, and their biological evaluation as cytotoxic and anthelmintic were performed.Highlights of the synthetic route include formation of the a-ketoamide linkage and use of stereocontrolled reactions.Open analogs of this natural product were obtained using a convergent strategy.

Toward the total synthesis of Scleritodermin A: preparation of the C1-N15 fragment

The synthesis of the C1-N15 fragment of the marine natural product Scleritodermin A has been accomplished through a short and stereocontrolled sequence. Highlights of this route include the synthesis of the novel ACT fragment and the formation of the α-keto amide linkage by the use of a highly activated α,β-ketonitrile.