93241-40-8Relevant articles and documents
A cytotoxic agent from Strychnos nux-vomica and biological evaluation of its modified analogues
Khan, M.,Srivastava, S. K.,Garg, A.,Darokar, M. P.
, p. 2975 - 2980,6 (2012)
Although a number of chemicals have been isolated from Strychnos nux-vomica, only a few have been evaluated for their biological significance. As a part of our drug discovery programme for cytotoxic agents from Indian medicinal plants, a novel cytotoxic agent, loganin 1 was isolated from the fruit pulp of S. nux-vomica. The loganin 1 showed significant anticancer activity against the human liver (WRL-68), colon (COLO-320 and CaCo2), ovarian (PA-1) and breast (MCF-7) cancer cell lines. Loganin 1 was further chemically transformed into eleven semi-synthetic derivatives 2-12 of which 2',3',4',7-tetra-Oacetyl- 6'-O-(3''', 4''', 5''')-trimethoxybenzoyl loganin 11 and 2',3',4',7-tetra-O- acetyl-6'-O-lauroyl loganin 6 derivatives showed eight, 13 and three times while 2',3',4',7- tetra-O-acetyl-6'-O-lauroyl loganin 6 showed equal, 13 and two times more activity against human suspension colon (CaCo2), adherent colon (COLO-320) and liver (WRL-68) cancer cell lines, respectively, than the known anticancer agent, vinblastine. The other analogues (except 4, 8 and 9) and loganin also showed marginal to moderate anticancer activity against the five tested human cancer cell lines.
