93242-59-2

Basic information

• Product Name: 1-ethyl-6,8-difluoro-7-(1H-imidazol-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• Synonyms: 3-quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(1H-imidazol-1-yl)-4-oxo-
• CAS NO: 93242-59-2
• Molecular Formula: C₁₅H₁₁F₂N₃O₃
• Molecular Weight: 319.2629
• Mol File: 93242-59-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 527.8°C at 760 mmHg
• Flash Point: 273°C
• Density: 1.5g/cm³
• Vapor Pressure: 5.74E-12mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 1-ethyl-6,8-difluoro-7-(1H-imidazol-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethyl-6,8-difluoro-7-(1H-imidazol-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(93242-59-2)
• EPA Substance Registry System: 1-ethyl-6,8-difluoro-7-(1H-imidazol-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(93242-59-2)

Safety Data

• Hazardous Substances Data: 93242-59-2(Hazardous Substances Data)

Usage

Chemical class

Fluoroquinolone antibiotic

Molecular structure

Consists of a quinoline core with a carboxylic acid group and various substituents, including an ethyl group, difluoro groups, and an imidazole ring.

Mechanism of action

Inhibits bacterial DNA gyrase and topoisomerase IV, disrupting bacterial DNA replication and transcription.

Effectiveness

Active against a wide range of bacterial infections.

Bactericidal effects

Penetrates and disrupts bacterial cell membranes, leading to cell death.

Potential side effects

Should be used with caution and under the guidance of a healthcare professional due to possible side effects.

Usage

Prescribed for treating bacterial infections, particularly those caused by gram-negative and gram-positive bacteria.

Precautions

May not be suitable for all patients, and healthcare professionals should consider individual patient factors and potential drug interactions before prescribing.

Dosage and administration

Dosage and administration should be determined by a healthcare professional based on the patient's condition, severity of infection, and other relevant factors.

Upstream product

• 288-32-4 1H-imidazole 
• 75338-42-0 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 

Relevant articles and documents

Synthesis of Antimicrobial Agents. 1. Syntheses and Antibacterial Activities of 7-(Azole substituted)quinolones

A series of 6-fluoro- and 6,8-difluoro-7-(azole substituted)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids were prepared.Structure-activity relationship studies indicated that the antibacterial potency was better when the 6,8-substituents were fluorine atoms and the 7-substituent was either 1-imidazolyl, 20, or 4-methyl-1-imidazolyl, 25.From the results of studies on pharmacokinetic profile and toxicity, 20 and 25 were found to possess excellent antibacterial activities and to show high blood levels after oral administration to mice with low toxicity.