93245-34-2Relevant academic research and scientific papers
STUDIES IN SPIROHETEROCYCLES: PART X: REACTIONS OF DIAZOMETHANE WITH 3-AROYLMETHYLENE-INDOL-2-ONES AND SYNTHESIS OF SOME NOVEL FLUORINE CONTAINING SPIRO-2'(1'H)-ONES
Joshi, Krishna C.,Jain, Renuka,Arora, Seema
, p. 1835 - 1839 (2007/10/02)
Reaction of ethereal diazomethane with fluorinated 3-aroylmethylene-indol-2-ones has been investigated for the first time yielding spiro-2'(1'H)-ones.The structures of all compounds have been confirmed on the basis of elemental
Studies in spiro heterocycles. Part 4(1): Investigation of the reactions of fluorinated 3-aroylmethylene-indol-2-ones with hydrazine and phenylhydrazine and synthesis of spiro [indole-3,3'-pyrazol]-2-ones.
Joshi,Jain,Garg
, p. 21 - 22 (2007/10/02)
Reactions of various 3-aroylmethylene-indol-2-ones with hydrazine and phenylhydrazine under exactly similar conditions have been carried out. The reaction with phenylhydrazine has not been investigated earlier. It was found that although the reaction with hydrazine hydrate afforded a spiro derivative viz., spiro[3H-indole-3,3'-(3H)pyrazol]-2(1H)-one, that with phenylhydrazine yielded simply a hydrazone derivative. Representative spiro compounds have been screened for antifertility activity but none was found active at a dose of 10 mg/kg in adult female rats.
