93269-35-3

Usage

Uses

(6α)-17,21-Dihydroxy-6-methylpregna-1,4,9(11)-triene-3,20-dione, is a metabolite of Prednisolone (P703740), which is a synthetic glucocorticoid, a derivative of cortisol, and can be used to treat a variety of inflammatory and auto-immune conditions. It is also the active metabolite of the drug prednisone.

Upstream product

• 93239-37-3 2-((6S,10R,13S)-17-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate 

Downstream Products

• 93239-34-0 17α,21-(ethoxybenzylidenedioxy)-6α-methyl-1,4,9(11)-pregnatriene-3,20-dione 

Relevant academic research and scientific papers

11a-hydroxy steroid diester

The present invention relates to 21-(3-carboxy-1-oxopropoxy) -17α-hydroxy-11α-(3,3-dimethyl-1-oxobutoxy)pregna-1,4-diene-3,20 dione and pharmaceutically acceptable salts thereof which are useful steroid prodrugs.

Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments

A method of inhibiting angiogenesis in a warm blooded animal which comprises administering to said animal an anti-angiogenic effective amount of a compound of the formula: STR1 wherein the dotted line between positions C-1 and C-2 means the presence or absence of a double bond; the ?bond at C-6 denotes α or β; wherein R1 is CH3 or --C2 H5 ; wherein R2 is H, and R3 is in the α-position and is --OH, --O-alkyl(C1 -C12), --OC(=O)alkyl(C1 -C12), --OC(=O)aryl, --OC(=O)N(R)2, or --OC(=O)OR7, wherein aryl is furyl, thienyl, pyrrolyl, or pyridyl wherein each of said hetero moiety is optionally substituted with one or two (C1 -C4)-alkyl groups or aryl is --(CH2)f -phenyl wherein f is 0 to 2 and wherein the phenyl ring is optionally substituted with one to three groups selected from chlorine, fluorine, bromine, alkyl(C1 -C3), alkoxy(C1 -C3), thioalkoxy(C1 -C3), Cl3 C--, F3 C--, --NH2 and --NHCOCH3 and wherein R is hydrogen, alkyl(C1 -C4), or phenyl and each R can be the same or different; and wherein R7 is aryl as herein defined or alkyl(C1 -C12); or wherein R2 is α-Cl and R3 is β-Cl; or wherein R2 and R3 taken together are oxygen (--O--) bridging positions C-9 and C-11; or wherein R2 and R3 taken together form a double bond between positions C-9 and C-11; wherein R4 is H, CH3, Cl or F; wherein R5 is H, OH, F, Cl, Br, CH3, phenyl, vinyl or allyl; wherein R6 is H or CH3 ; wherein R9 is H, OH, CH3 F or =CH2 ; and wherein R10 is H, OH, CH3 or R10 forms a second bond between positions C-16 and C-17.

Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid

This invention discloses an improved process for the production of corticoids from 17α-hydroxy steroids utilizing peroxymonosulfate.