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93272-54-9

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93272-54-9 Usage

Structure

Contains an isoindole-1,3-dione core with a hydroxybutyl side chain and a nitroimidazole group

Bioactivity

Potential antimicrobial and antiparasitic properties due to the nitroimidazole moiety

Pharmacological activity

Potential due to presence of hydroxy group and isoindole-1,3-dione framework

Applications

Potential in drug discovery and development for new antimicrobial and antiparasitic agents

Research

Further studies needed to fully understand and utilize the properties of this compound.

Check Digit Verification of cas no

The CAS Registry Mumber 93272-54-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,2,7 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 93272-54:
(7*9)+(6*3)+(5*2)+(4*7)+(3*2)+(2*5)+(1*4)=139
139 % 10 = 9
So 93272-54-9 is a valid CAS Registry Number.

93272-54-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[2-hydroxy-4-(2-nitroimidazol-1-yl)butyl]isoindole-1,3-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:93272-54-9 SDS

93272-54-9Downstream Products

93272-54-9Relevant articles and documents

Radiosensitizers of hypoxic mammalian cells. 1-(hydroxyaminoalkyl)-substituted nitroimidazoles

Ahmed,Stratford,Jenkins

, p. 1763 - 1768 (2007/10/02)

A series of novel 1-(hydroxyaminoalkyl)-substituted nitroimidazoles has been synthesized as potential radiosensitizers for hypoxic mammalian cells. These compounds were synthesized via N-(hydroxyalkyl)phthalimide nitroimidazole intermediates which, on reaction with hydrazine hydrate, yielded the corresponding amines. The intermediates were prepared by reacting the epoxide derived from nitroimidazole with phthalimide and/or the epoxide derived from phthalimide with the nitroimidazole. The method was used successfully for the preparation of 2-, 4- and 5-nitroimidazole derivatives. In a modification of this procedure, 1-(2-aminoethyl)-2-nitroimidazole has been prepared by a new route which avoids the use of aziridine. These agents were tested for cytotoxicity and radiosensitizing ability in vitro using Chinese hamster V79 cells. All of the 2-nitroimidazoles tested showed toxicity similar to that previously reported for misonidazole and Ro 03-8799 (1-(2-hydroxy-3-piperidinopropyl)-2-nitroimidazole), two compounds currently undergoing clinical evaluation. In addition, all the novel primary amines were shown to function as hypoxic cell radiosensitizers. The 2-nitroimidazole derivatives were the most efficient compounds to be examined and showed at least as much activity as misonidazole.

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