932720-97-3

Upstream product

• 114873-04-0 (R)-2-(tert-butoxycarbonylamino)-3-(2,4-dichlorophenyl)propionic acid 
• 45766-35-6 5-Amino-2.3-dihydro-1H-isoindole 
• 127168-68-7 2,3-Dihydro-5-nitro-2-(phenylmethyl)-1H-isoindole 
• 932720-96-2 (R)-tert-butyl 3-(2,4-dichlorophenyl)-1-(5-nitroisoindolin-2-yl)-1-oxopropan-2yl-carbamate 

Relevant academic research and scientific papers

Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an α-amino amide as the zinc-binding unit

A series of potent inhibitors of histone deacetylase-8 (HDAC8) is described that contains an α-amino amide zinc-binding unit and a substituted isoindolinyl capping group. The presence of a 2,4-dichlorophenyl unit located in the acetate-release cavity was

CARBOXYAMINE COMPOUNDS AND METHODS OF USE THEREOF

The invention relates to the use of carboxyamine compounds and salts thereof in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.