93276-53-0Relevant academic research and scientific papers
Synthesis and antibacterial activity of some imidazo[1,2-a[pyrimidine derivatives
Rival,Grassy,Michel
, p. 1170 - 1176 (2007/10/02)
A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized. The 'in vitro' antibacterial activity of these compounds and their corresponding α-bromoketones against a variety of gram (+), gram (-) bacteria and Mycobacterium species is reported. Some of the prepared derivatives exhibited potent antimicrobial activity.
Inotropic 2-arylimidazo[1,2-a]pyrimidines
Barraclough,Black,Cambridge,Capon,Cox,Firmin,Gerskowitch,Giles,Glen,Hill,Hull,Iyer,Kettle,King,Nobbs,Randall,Skone,Smith,Vine,et al.
, p. 207 - 217 (2007/10/02)
A series of 2-arylimidazo[1,2-a]pyrimidines has been prepared and evaluated for inotropic activity. Three of these heterocycles, ether 19, sulphide 21 and mesylate 24 displayed more potent inotropic effects in vitro than isomazole. The in vivo inotropic p
Imidazopyrimidines and Imidazopyrazines: The Role of Nitrogen Position in Inotropic Activity
Spitzer, Wayne A.,Victor, Frantz,Pollock, G. Don,Hayes, J. Scott
, p. 1590 - 1595 (2007/10/02)
Congestive heart failure is a major medical problem for which existing medicaments have provided limited benefit.Recent new experimental drugs, including imidazo- and imidazopyridines, have both inotropic and vasodilatory properties.Subtle c
Inotropic agents
-
, (2008/06/13)
This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.
