93277-17-9Relevant academic research and scientific papers
Adenosine receptor ligands and their use in the treatment of disease
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, (2008/06/13)
The invention relates to cyclic heteroaromatic compounds, containing at least one nitrogen atom, and to their use in the manufacture of medicaments for the treatment of diseases, related to adenosine receptor modulators, such as Alzheimer's disease, Parkinson's disease, neuroprotection, schizophrenia, anxiety, pain, respiration deficits, depression, asthma, allergic responses, hypoxia, ischaemia, seizure, substance abuse, sedation and they may be active as muscle relaxants, antipsychotics, anti epileptics, anticonvulsants and cardiaprotective agents.
Novel alpha-cyano-beta-oxopropionamides
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, (2008/06/13)
α-(Substituted carbamoyl)-β-aryl- and heteroaryl-β-oxo-propionitriles of formula, , A-CO- enol ethers thereof and salts thereof, as well as pharmaceutical preparations containing same and methods of preparing and using these compounds are disclosed. Said compounds represent novel antiinflammatory and antirheumatic agents. Their property to interfere with both the cyclooxygenase and lipoxygenase pathway of the arachidonic fatty acid bioconversion to inflammatory mediators make them valuable therapeutics. These properties render the mentioned substituted carbamoyl-β-oxopropionitriles useful for the treatment of arthritic and rheumatic diseases and other inflammatory conditions in mammals.
β-Fur-2-yl-α-halogenacrylonitriles. IV. Reactions of β-Fur-2-yl-α-halogenacrylonitriles with Alcohols and Phenols
Jaehnisch, K.,Callejas, D.R.,Catasus, N.
, p. 899 - 903 (2007/10/02)
β-Fur-2-yl-α-halogenacrylonitriles 1a-c react with alcohols and phenols to yield β-fur-2-yl-β-alkoxyacrylonitriles and β-fur-2-yl-β-aroxyacrylonitriles 2a-k respectively.With ethylene glycol α-acetonitriles 3a,b are formed.
β-Fur-2-yl-α-halogenacrylonitriles. I. Preparation of β-Fur-2-yl-β-aminoacrylonitriles and β-Fur-2-yl-α-aminoacrylonitriles
Jaehnisch, K.,Seeboth, H.,Krause, E.,Callejas, D. R.
, p. 556 - 560 (2007/10/02)
β-Fur-2-yl-α-halogenacrylonitriles 1 react with secondary amines to yield β-fur-2-yl-β-aminonitriles 2 and β-fur-2-yl-α-aminoacrylonitriles 3.The 1H-n.m.r. spectra of the E/Z isomers are discussed.
