93290-96-1Relevant academic research and scientific papers
Iodine-Promoted One-pot Synthesis of Highly Substituted 4-Aminopyrroles and Bis-4-aminopyrrole from Aryl Methyl Ketones, Arylamines, and Enamines
Jalani, Hitesh B.,Mali, Jyotirling R.,Park, Hyejun,Lee, Jae Kyun,Lee, Kiho,Lee, Kyeong,Choi, Yongseok
, p. 4073 - 4079 (2018)
An iodine-promoted one-pot synthesis of functionally diverse and highly substituted 4-aminopyrroles directly from aryl methyl ketones, arylamines, and enamines was developed. The reaction involves in-situ oxidation of aryl methyl ketone to glyoxal, subsequent imine formation by aniline, followed by nucleophilic addition of enamine, and cyclization to afford highly substituted 4-aminopyrroles. This reaction involved the formation of two C?N bonds and one C?C bond by a formal [1+1+3] annulation approach. The present method provides an interesting framework of two 4-aminopyrrole units directly attached to a biphenyl core by the reaction of 4,4′-diacyl biphenyl, amine, and enamine groups. This Hantzsch-type one-pot reaction provides diverse 4-aminopyrroles, which could be useful in medicinal/material chemistry. (Figure presented.).
Inhibitors of anthrax lethal factor activity
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, (2008/06/13)
Methods and compositions that act as specific inhibitors of ALF activity for the prophylaxis and treatment of anthrax infections.
