933-69-7

Basic information

• Product Name: 5-METHYL-IMIDAZO[1,2-A]PYRIDINE
• Synonyms: 5-METHYL-IMIDAZO[1,2-A]PYRIDINE
• CAS NO: 933-69-7
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16
• Mol File: 933-69-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 96°C/0.7mm
• Flash Point: °C
• Appearance: /
• Density: 1.11g/cm³
• Refractive Index: 1.609
• PKA: 7.44±0.50(Predicted)
• CAS DataBase Reference: 5-METHYL-IMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-IMIDAZO[1,2-A]PYRIDINE(933-69-7)
• EPA Substance Registry System: 5-METHYL-IMIDAZO[1,2-A]PYRIDINE(933-69-7)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 933-69-7(Hazardous Substances Data)

Usage

General Description

5-Methyl-Imidazo[1,2-a]pyridine is a synthetic, aromatic compound that belongs to the class of organic compounds known as imidazo[1,2-a]pyridines. These are organic compounds containing an imidazo ring fused to a pyridine ring. 5-Methyl-Imidazo is characterized by a 5-membered ring structure with nitrogen atoms at positions 1 and 2. The chemical formula for this compound is C8H8N2. Its molecular weight is 132.162 g/mol. It is used in various research studies and industrial applications, however, its specific biological functions or applications in pharmaceuticals are not well defined. Its hazard and toxicity information, as well as environmental impacts, largely remain unknown. Therefore, it is recommended for handling and storage with appropriate safety measures.

InChI:InChI=1/C8H8N2/c1-7-3-2-4-8-9-5-6-10(7)8/h2-6H,1H3

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 17157-48-1 bromoacetaldehyde 
• 107-20-0 2-chloroethanal 

Downstream Products

• 1338248-81-9 5-methyl-3-phenylimidazo[1,2-a]pyridine 
• 1467064-03-4 3-(3-chlorophenyl)-5-methylimidazo[1,2-a]pyridine 
• 1414949-17-9 3-(4-Chlorophenyl)-2-phenylimidazo[1,2-a]pyridine 
• 1467064-05-6 3-(3-fluorophenyl)-5-methylimidazo[1,2-a]pyridine 
• 1467064-04-5 3-(2-chlorophenyl)-5-methylimidazo[1,2-a]pyridine 
• 178488-39-6 5-methylimidazo[1,2-a]pyridin-3-yl methanol 

Relevant articles and documents

Enantioselective Hydrogenation of Imidazo[1,2-a]pyridines

The enantioselective synthesis of tetrahydroimidazo[1,2-a]pyridines by direct hydrogenation was achieved using a ruthenium/N-heterocyclic carbene (NHC) catalyst. The reaction forgoes the need for protecting or activating groups, proceeds with complete regioselectivity, good to excellent yields, enantiomeric ratios of up to 98:2, and tolerates a broad range of functional groups. 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridines, which are found in numerous bioactive molecules, were directly obtained by this method, and its applicability was demonstrated by the (formal) synthesis of several functional molecules.

Reactions with N-chlorosuccinimide of various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position

Chlorination reactions using N-chlorosuccinimide (NCS) was investigated for various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position. These reactions showed different results, and by examining these, we proposed a reaction mechanism via the appropriate 3-halogenoimidazo[1,2-a]pyridium compounds as the reaction intermediates.

Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents

The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.