93302-47-7 Usage
Uses
Used in Pharmaceutical Industry:
Naloxone methiodide is used as an opioid antagonist for the treatment of opioid overdose. It works by binding to and blocking the opioid receptors in the brain, reversing the effects of opioids and preventing further intoxication.
Used in Research Applications:
Naloxone methiodide is used as an inhibitor of opioid receptors in various research studies involving fish and mice. It helps in understanding the role of opioid neurotransmission in these species and provides insights into the development of new therapeutic strategies for opioid addiction and dependence.
Additionally, naloxone methiodide is used to block opioid neurotransmission in research settings, allowing scientists to study the effects of opioids on the nervous system and develop new treatments for opioid-related disorders.
Biochem/physiol Actions
Naloxone methiodide has low affinity for opioid receptors than naloxone. Administration of naloxone inhibits opioid receptor and opioid-induced respiratory depression.
Check Digit Verification of cas no
The CAS Registry Mumber 93302-47-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,3,0 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 93302-47:
(7*9)+(6*3)+(5*3)+(4*0)+(3*2)+(2*4)+(1*7)=117
117 % 10 = 7
So 93302-47-7 is a valid CAS Registry Number.
93302-47-7Relevant articles and documents
A (1)H AND (13)C NUCLEAR MAGNETIC RESONANCE STUDY OF THREE QUATERNARY SALTS OF NALOXONE AND OXYMORPHONE
Funke, Carel W.,de Graaf, Joop S.,Buurman, Edward,Thalen, Henk,Vrijhof, Pieter
, p. 735 - 738 (1986)
The information from (1)H-(1)H and (1)H-(13)c correlation n.m.r. spectra allowed a complete assignment of the (1)H and (13)C spectra of three N,N-dialkylmorphinanium chloride derivatives (one N,N-diallyl and two N-allyl-N-methyl diastereoisomers).In the case of the stereoisomers the configuration of the asymmetric N atom could be established on the basis of (1)H chemical shift data and nuclear Overhauser effects.
Narcotic agonist/antagonist properties of quaternary diastereoisomers derived from oxymorphone and naloxone
Iorio,Frigeni
, p. 301 - 303 (2007/10/02)
Quaternary derivatives of oxymorphone and naloxone were tested for their narcotic agonist/antagonist properties with in vitro and in vivo assays. Correlations between agonist/antagonist activity ratio and N-substituent orientation follow the same pattern as that found for diastereoisomeric quaternary morphinium salts: compounds with larger groups in the equatorial position displayed more antagonist activity than the corresponding diastereoisomers.
