933035-05-3

Upstream product

• 933034-89-0 8-bromo-6-chloro-imidazo[1,2-b]pyridazine hydrochloride 
• 2393-23-9 4-methoxy-benzylamine 
• 933190-51-3 8-bromo-6-chloro-imidazo[1,2-b]pyridazine 

Relevant academic research and scientific papers

CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS

The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.

Fused heterocyclic compounds useful as kinase modulators

Compounds having the formula (1), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, are usefuil as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, Z is N or CR3, and R1, R2, R3, X and Y are as defined herein.