933045-60-4Relevant academic research and scientific papers
Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase
Ruiz-Caro, Juliana,Basavapathruni, Aravind,Kim, Joseph T.,Bailey, Christopher M.,Wang, Ligong,Anderson, Karen S.,Hamilton, Andrew D.,Jorgensen, William L.
, p. 668 - 671 (2007/10/03)
Following computational analyses, potential non-nucleoside inhibitors of HIV-1 reverse transcriptase have been pursued through synthesis and assaying for anti-viral activity. The general class Het-NH-Ph-U has been considered, where Het is an aromatic heterocycle and U is an unsaturated, hydrophobic group. Results for compounds with Het = 2-thiazoyl and 2-pyrimidinyl are the focus of this report.
