933058-16-3Relevant academic research and scientific papers
Synthesis of reference standards to enable single cell metabolomic studies of tetramethylrhodamine-labeled ganglioside GM1
Larsson, E. Andreas,Olsson, Ulf,Whitmore, Colin D.,Martins, Rita,Tettamanti, Guido,Schnaar, Ronald L.,Dovichi, Norman J.,Palcic, Monica M.,Hindsgaul, Ole
, p. 482 - 489 (2007)
Ganglioside GM1 and its seven potential catabolic products: asialo-GM1, GM2, asialo-GM2, GM3, Lac-Cer, Glc-Cer and Cer, were labeled with tetramethylrhodamine (TMR) to permit ultra-sensitive analysis using laser-induced fluorescence (LIF) detection. The p
A concise chemical synthesis of a fluorescent βgal-(1,4)-S-βGlc- Cer derivative and its enzymatic elongation by glycosyltransferases
Tanaka, Hidenori,Yoshimura, Yayoi,Dovichi, Norman J.,Palcic, Monica M.,Hindsgaul, Ole
supporting information; experimental part, p. 1812 - 1815 (2012/05/04)
A straightforward chemical synthesis of lyso-lactosylceramide with the terminal galactose linked to glucose through a β-S-glycosidic bond is reported. The product is labeled on the amino-group with tetramethylrhodamine enabling its ultrasensitive detection in capillary electrophoresis using laser-induced fluorescence. The fluorescent product disaccharide is resistant to hydrolysis by glycosidases but is shown to remain as an acceptor substrate for glycosyltransferases for the conversion into the trisaccharides GM3 and Gb3.
