93315-78-7

Basic information

• Product Name: 1H-Indole-3-carboxaldehyde, 1-methyl-4-(phenylmethoxy)-
• CAS NO: 93315-78-7
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.312
• Mol File: 93315-78-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Indole-3-carboxaldehyde, 1-methyl-4-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-carboxaldehyde, 1-methyl-4-(phenylmethoxy)-(93315-78-7)
• EPA Substance Registry System: 1H-Indole-3-carboxaldehyde, 1-methyl-4-(phenylmethoxy)-(93315-78-7)

Safety Data

• Hazardous Substances Data: 93315-78-7(Hazardous Substances Data)

Usage

Molecular Structure

1H-Indole-3-carboxaldehyde, 1-methyl-4-(phenylmethoxy)consists of an indole ring with a carboxaldehyde group and a methyl and phenylmethoxy substitution at the 1 and 4 positions, respectively.

Usage

It is commonly used in organic synthesis and pharmaceutical research due to its potential biological and pharmacological properties.

Building Block

It acts as a versatile building block in the synthesis of various heterocyclic compounds, making it a valuable tool in the development of new drugs and compounds for medical applications.

Scientific Study

Its unique chemical structure and reactivity make it an interesting and important molecule for further scientific study and research.

Upstream product

• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 13523-93-8 4-(benzyloxy)-1-methyl-1H-indole 
• 109523-69-5 4-hydroxy-1-methyl-1H-indole-3-carbaldehyde 
• 7042-71-9 4-benzyloxyindole-3-carbaldehyde 
• 74-88-4 methyl iodide 

Downstream Products

• 1312614-10-0 C₁₈H₂₀N₂O 
• 1312614-01-9 C₂₆H₂₂N₂O₃ 
• 1312614-06-4 C₄₆H₄₂N₄O₆ 
• 1312614-04-2 C₄₆H₄₂N₄O₆ 
• 1352136-40-3 C₂₃H₁₈N₄O₂S 
• 1352136-41-4 C₂₄H₁₇F₃N₄O₂S 
• 1352136-42-5 C₂₄H₂₂N₆O₂S 
• 1352136-43-6 C₂₄H₁₉N₃O₂S 
• 1352136-39-0 C₂₅H₂₀N₄O₂ 

Relevant articles and documents

Visible Light-Driven C-3 Functionalization of Indoles over Conjugated Microporous Polymers

Metal-free and heterogeneous organic photocatalysts provide an environmentally friendly alternative to traditional metal-based catalysts. This paper reports a series of carbazole-based conjugated microporous polymers (CMPs) with tunable redox potentials and explores their photocatalytic performance with regard to C-3 formylation and thiocyanation of indoles. Conjugated polymers were synthesized through FeCl3 mediated Friedel-Crafts reactions, and their redox potentials were well regulated by simply altering the nature of the core (i.e., 1,4-dibenzyl, 1,3,5-tribenzyl, or 1,3,5-triazin-2,4,6-triyl). The resulting CMPs exhibited high surface areas, visible light absorptions, and tunable semiconductor-range band gaps. With the highest oxidative capability, CMP-CSU6 derived from 1,3,5-tri(9H-carbazol-9-yl)benzene showed the highest efficiency for C-3 formylation and thiocyanation of indoles at room temperature. Notably, the as-made catalysts can be easily recovered with good retention of photocatalytic activity and reused at least five times, suggesting good recyclability. These results are significant for constructing high-performance porous polymer catalysts with tunable photoredox potentials targeting an efficient material design for catalysis.

Towards total synthesis of communesins and perophoramidine: Unexpected cascade reaction of Michael-Mannich-Mannich additions

A new type of chiral amidinobenzodiene 5 was prepared from isatin in ten steps. While attempting to prepare the core structure from 5 and tryptamine derivative 17 via a hetero Diels-Alder reaction for the total synthesis of communesin and perophoramidine, we observed an unexpected three-step, one-pot cascade reaction of Michael-Manich-Manich additions. The cascade reaction between 5 and 17 yielded diasteromers 21a and 21b with a complex polycyclic skeleton of 2,3,4,5-diindolinohexahydropyrrole in 76% yield and a ratio of 3:1. The stereochemistry of 21a was confirmed by X-ray crystal-structural analysis. Georg Thieme Verlag Stuttgart · New York.

PYRAZOLOPYRIDINE DERIVATIVES AS INHIBITORS OF BETA-ADRENERGIC RECEPTOR KINASE 1

The invention relates to 6-amido substituted pyrazolopyridine derivatives of the formula (I) useful as inhibitors of beta-adrenergic receptor kinase 1 (βARK-1 ), compositions containing such-compounds and their use for the treatment and prevention of chro