933236-19-2Relevant articles and documents
Structure-based design of indole propionic acids as novel PPARα/γ co-agonists
Kuhn, Bernd,Hilpert, Hans,Benz, Joerg,Binggeli, Alfred,Grether, Uwe,Humm, Roland,Maerki, Hans Peter,Meyer, Markus,Mohr, Peter
, p. 4016 - 4020 (2006)
In the quest for novel PPARα/γ co-agonists as putative drugs for the treatment of type 2 diabetes and dyslipidemia, we have used a structure-based design approach to identify propionic acids with a 1,5-disubstituted indole scaffold as potent PPARα/γ activ