93331-08-9Relevant academic research and scientific papers
Overcoming the Limitations of C?H Activation with Strongly Coordinating N-Heterocycles by Cobalt Catalysis
Wang, Hui,Lorion, Mélanie M.,Ackermann, Lutz
, p. 10386 - 10390 (2016)
Strongly coordinating nitrogen heterocycles, including pyrimidines, oxazolines, pyrazoles, and pyridines, were fully tolerated in cobalt-catalyzed C?H amidations by imidate assistance. Structurally complex quinazolines are thus accessible in a step-economic manner. Our findings also establish the relative powers of directing groups in cobalt(III)-catalyzed C?H functionalization for the first time.
Efficient Synthesis of Quinazolines from Aryl Imidates and N-Alkoxyamide by Ir(III)-Catalyzed C?H Amidation/Cyclization
Fan, Wei-Tai,Huang, Zhibin,Xu, Xu,Tu, Guangliang,Geng, Jingyao,Ji, Shun-Jun,Zhao, Yingsheng
supporting information, p. 4144 - 4147 (2021/08/24)
An Ir(III) catalyst was used for the first time to realize the synthesis of quinazolines by C?H bond activation/cyclization with N-alkoxyamides as amidation reagents. This reaction has the advantages of wide substrate adaptability, good to excellent yield
Co(III)-Catalyzed Synthesis of Quinazolines via C-H Activation of N-Sulfinylimines and Benzimidates
Wang, Fen,Wang, He,Wang, Qiang,Yu, Songjie,Li, Xingwei
supporting information, p. 1306 - 1309 (2016/04/01)
C-H activation of arenes has been established as an important strategy for heterocycle synthesis via annulations between arenes and unsaturated coupling partners. However, nitriles failed to act as such a coupling partner. Dioxazolones have been employed as a synthon of nitriles, and subsequent coupling with arenes such as N-sulfinylimines and benzimidates bearing a functionalizable directing group provided facile access to two classes of quinazolines under Co(III)-catalysis.
