933443-26-6

Basic information

• Product Name: C₃H₇O₃P*C₈H₁₁N
• CAS NO: 933443-26-6
• Molecular Weight: 243.243
• Mol File: 933443-26-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: >137°C (Dec.)
• CAS DataBase Reference: C₃H₇O₃P*C₈H₁₁N(CAS DataBase Reference)
• NIST Chemistry Reference: C₃H₇O₃P*C₈H₁₁N(933443-26-6)
• EPA Substance Registry System: C₃H₇O₃P*C₈H₁₁N(933443-26-6)

Safety Data

• Hazardous Substances Data: 933443-26-6(Hazardous Substances Data)

Usage

Description

C₃H₇O₃PC₈H₁₁N, also known as cis-Propenylphosphonic Acid (R)-(+)-α-Methylbenzylamine Salt, is a chemical compound that serves as a reagent in the microbial production of Fosfomycin.

Uses

Used in Pharmaceutical Industry:
C₃H₇O₃PC₈H₁₁N is used as a reagent for the microbial production of Fosfomycin, an antibiotic used in the treatment of urinary tract infections. Its role in the production process is crucial for obtaining the desired antibiotic compound, which helps combat bacterial infections effectively.

Upstream product

• 25383-06-6 cis-1-propenylphosphonic acid 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Relevant articles and documents

Production method of fosfomycin calcium bulk drug

The invention discloses a production method of a fosfomycin calcium bulk drug. The method comprises the following steps: adding a resolution reagent phenylethylamine into a reaction solution of cis-propenylphosphonic acid to form a racemate, and then adding an oxidation reagent to form epoxy propenylphosphonic acid, wherein the generation of a racemic mixture through epoxidation of the cis-propenylphosphonic acid is the key step of the whole synthesis reaction, the addition of the catalyst can realize epoxidation of cis-propenylphosphonic acid at a low temperature, the ZSM-5 molecular sieve is added as a catalyst carrier so as to make the catalyst keep a good crystal structure, sodium tungstate and sodium molybdate are well dispersed in pore channels of the ZSM-5 molecular sieve so as to avid the influence of mixing of the catalyst and the product on the purity of the product effectively recover the catalyst and recycle the catalyst and achieve environment-friendly and economical characteristics, and the yield of the fosfomycin calcium raw material medicine prepared by the production method reaches 49.6-51.2%.