933469-70-6

Basic information

• Product Name: (4R)-(tert-butyldimethylsilanyloxy)-1-(2-cyanoethyl)pyrrolidin-(2S)-carboxylic acid allyl ester
• Synonyms: (4R)-(tert-butyldimethylsilanyloxy)-1-(2-cyanoethyl)pyrrolidin-(2S)-carboxylic acid allyl ester
• CAS NO: 933469-70-6
• Molecular Weight: 338.522
• Mol File: 933469-70-6.mol

Chemical Properties

• CAS DataBase Reference: (4R)-(tert-butyldimethylsilanyloxy)-1-(2-cyanoethyl)pyrrolidin-(2S)-carboxylic acid allyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-(tert-butyldimethylsilanyloxy)-1-(2-cyanoethyl)pyrrolidin-(2S)-carboxylic acid allyl ester(933469-70-6)
• EPA Substance Registry System: (4R)-(tert-butyldimethylsilanyloxy)-1-(2-cyanoethyl)pyrrolidin-(2S)-carboxylic acid allyl ester(933469-70-6)

Safety Data

• Hazardous Substances Data: 933469-70-6(Hazardous Substances Data)

Upstream product

• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 

Relevant articles and documents

The diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope elimination/intramolecular nitrone cycloaddition strategy

Functionalised hydroxylamine derivatives of (S)-proline and pipecolic acid have been prepared using a Cope elimination. These hydroxylamines have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. An intramolecular 1,3-dipolar cycloaddition then occurs between the nitrone and pendant double bond to give tricyclic lactams and lactones with high diastereoselectivity.