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Upstream product

• 226393-33-5 (R,R)-(+)-1-hydroxy-1-oxo-2,5-trans-diphenylphospholane 

Relevant academic research and scientific papers

1,2-Bis(2,5-diphenylphospholano)methane, a new ligand for asymmetric hydrogenation

1,2-Bis(2,5-diphenylphospholano)methane (Ph-BPM) has been prepared in good yield from 2,5-trans-diphenylphospholane-borane adduct. Rhodium and ruthenium complexes of this ligand have been prepared and their usefulness in asymmetric hydrogenation has been investigated. [Ph-BPM Rh(COD)]BF4 showed high activity and selectivity for itaconate and dehydroamino acid hydrogenation. Ph-BPM RuCl2(DPEN) was effective for imine hydrogenation.

BISPHOSPHOLANES FOR USE AS CATALYSTS IN ASYMMETRIC REACTIONS

The invention is a set of novel bisphospholane ligands that can be complexed with transition metals. These complexes are useful as catalysts in asymmetric reactions such as asymmetric hydrogenation.