933673-35-9

Basic information

• Product Name: 2-(3,5-BIS-TRIFLUOROMETHYL-PHENOXYMETHYL)-OXIRANE
• Synonyms: 2-(3,5-BIS-TRIFLUOROMETHYL-PHENOXYMETHYL)-OXIRANE
• CAS NO: 933673-35-9
• Molecular Formula: C11H8F6O2
• Molecular Weight: 286.17
• Mol File: 933673-35-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3,5-BIS-TRIFLUOROMETHYL-PHENOXYMETHYL)-OXIRANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-BIS-TRIFLUOROMETHYL-PHENOXYMETHYL)-OXIRANE(933673-35-9)
• EPA Substance Registry System: 2-(3,5-BIS-TRIFLUOROMETHYL-PHENOXYMETHYL)-OXIRANE(933673-35-9)

Safety Data

• Hazardous Substances Data: 933673-35-9(Hazardous Substances Data)

Usage

Type of compound

Fluorinated epoxide

Reactivity

Highly reactive due to the presence of the epoxide group

Stability

Known for its stability and resistance to hydrolysis

Uses

Building block in the synthesis of various organic compounds and materials, reagent in organic synthesis, monomer in the production of polymer materials

Industry applications

Pharmaceutical, agrochemical, and materials industries

Versatility

A versatile and important chemical compound

Upstream product

• 51594-55-9 (R)-(-)-epichlorohydrin 
• 349-58-6 3,5-bis-(trifluoromethyl)phenol 
• 67843-74-7 (S)-epichlorohydrin 

Relevant articles and documents

Design, synthesis, and antibacterial evaluation of novel derivatives of NPS-2143 for the treatment of methicillin-resistant S. aureus (MRSA) infection

Methicillin-resistant Staphylococcus aureus (MRSA) infections are a significant global health challenge due to the emergence of strains exhibiting resistance to nearly all classes of antibiotics. This necessitates the rapid development of novel antimicrobials to circumvent this critical problem. Screening of compounds based on phenotypes is one of the major strategies for finding new antibiotics at present. Hence, we here performed a phenotypic screening against MRSA and identified NPS-2143 exhibiting activity against MRSA with an MIC value of 16 μg ml?1. In order to discover more potent anti-MRSA agents, a series of derivatives of NPS-2143 were designed and synthesized. The most promising compounds 48 and 49 exhibited favorable antimicrobial activity with an MIC value of 2 μg ml?1.