933688-11-0

Upstream product

• 1438084-90-2 tert-butyl 3,4-bis(hydroxymethyl)piperidine-1-carboxylate 
• 1438084-85-5 1-tert-butyl 3,4-dimethyl piperidine-1,3,4-tricarboxylate 
• 1438084-80-0 dimethyl piperidine-3,4-dicarboxylate 
• 490-11-9 3,4-pyridinecarboxylic acid 
• 1796-83-4 dimethyl 3,4-pyridinedicarboxylate 

Downstream Products

• 1438073-98-3 N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydrofuro[3,4-c]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438074-34-0 N-(4-fluorophenyl)-6-(3-(hexahydrofuro[3,4-c]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438074-51-1 N-(3-ethynyl-4-fluorophenyl)-6-(3-(hexahydrofuro[3,4-c]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438074-69-1 N-(3-ethynylphenyl)-6-(3-(hexahydrofuro[3,4-c]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438074-87-3 N-(4-bromo-2-fluorophenyl)-6-(3-(hexahydrofuro[3,4-c]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine 

Relevant academic research and scientific papers

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter-and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.