933710-78-2

Basic information

• Product Name: 2-CHLORO-1H-BENZIMIDAZOLE-5-CARBOXYLIC ACID
• Synonyms: 2-CHLORO-1H-BENZIMIDAZOLE-5-CARBOXYLIC ACID;2-chloro-3H-benzo[d]imidazole-5-carboxylic acid;2-chloro-1H-benzo[d]imidazole-5-carboxylic acid;2-Chloro-1H-benzoimidazole-5-carboxylic acid
• CAS NO: 933710-78-2
• Molecular Formula: C8H5ClN2O2
• Molecular Weight: 196.59
• Mol File: 933710-78-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLORO-1H-BENZIMIDAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-1H-BENZIMIDAZOLE-5-CARBOXYLIC ACID(933710-78-2)
• EPA Substance Registry System: 2-CHLORO-1H-BENZIMIDAZOLE-5-CARBOXYLIC ACID(933710-78-2)

Safety Data

• Hazardous Substances Data: 933710-78-2(Hazardous Substances Data)

Usage

General Description

2-Chloro-1H-benzimidazole-5-carboxylic acid is a chemical compound that belongs to the benzimidazole and carboxylic acid class of compounds. It is characterized by a benzimidazole ring system with a carboxylic acid functional group and a chlorine atom attached to the benzene ring. 2-CHLORO-1H-BENZIMIDAZOLE-5-CARBOXYLIC ACID has potential applications in the pharmaceutical industry, particularly in the development of drugs targeting various biological pathways. Its chemical structure and properties make it a useful scaffold for the synthesis of new drugs with potential biological activity. Additionally, it can also be used as a building block in organic synthesis for the production of various compounds with diverse applications.

Upstream product

• 619-05-6 3,4-diaminobenzoic acid 
• 683242-75-3 methyl 2-chloro-1H-benzo[d]imidazole-5-carboxylate 
• 106429-57-6 1,3-dihydro-2-oxo-2H-benzimidazole-5-carboxylic acid methyl ester 
• 36692-49-6 Methyl 3,4-diaminobenzoate 
• 23814-14-4 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylic acid 

Downstream Products

• 99122-17-5 2-hydrazineyl-1H-benzo[d]imidazole-5-carboxylic acid 

Relevant articles and documents

COMPOUNDS AS RAS INHIBITORS AND USE THEREOF

A compound of Formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole derivatives

Design, syntheses, and structure-activity relationships of a novel class of 2-{3-oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole NPY Y5 receptor antagonists are described. The benzimidazole structures were newly designed based on the urea linkage of our prototype Y5 receptor antagonists (2 and 3). By optimizing substituents on the benzimidazole core part of the lead compound 5a, we were able to develop a potent, orally available, and brain-penetrable Y5 selective antagonist (5k). Crown Copyright