933751-46-3

Upstream product

• 711-38-6 4'-methoxy-2,2,2-trifluoroacetophenone 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 16208-17-6 2,2-dihydroxy-1-(4-methoxyphenyl)ethan-1-one 

Downstream Products

• 1337534-56-1 3-(4,5-dimethyl-3-oxido-1H-imidazol-1-yl)-1,1,1-trifluoro-2-(4-methoxyphenyl)propan-2-ol 
• 1337534-60-7 3-(4-acetyl-2,3-dihydro-5-methyl-2-oxo-1H-imidazol-1-yl)-1,1,1-trifluoro-2-(4-methoxyphenyl)propan-2-ol 
• 1337534-59-4 3-(4-ethoxycarbonyl-2,3-dihydro-5-methyl-2-oxo-1H-imidazol-1-yl)-1,1,1-trifluoro-2-(4-methoxyphenyl)propan-2-ol 

Relevant academic research and scientific papers

New β-amino-α-trifluoromethyl alcohols and their exploration in the synthesis of trifluoromethylated imidazole derivatives

Racemic and enantiomerically pure β-amino-α-trifluoromethyl alcohols were obtained via sequential nucleophilic trifluoromethylation of selected α-imino ketones, derived from arylglyoxals, and subsequent removal of the MeO or Ph(Me)CH substituent, respecti

Unusual behaviour of N-cinnamoyl-2-hydroxy-2- (trifluoromethyl)arylethylamines in Pictet-Gams cyclization. Synthesis of 2- styryl-5-aryl-5-trifluoromethyl-2-oxazolines

Cyclization of N-acyl-2-hydroxy-2-(trifluoromethyl)arylethylamines 4 under Pictet-Gams conditions afforded 2-oxazolines 5 instead of the expected isoquinolines 6. The effect of the trifluoromethyl group on the result of the reaction is discussed.