933789-26-5

Basic information

• Product Name: ENONE-L
• Synonyms: ENONE-L;(3aR,4R,5R,6aS)-5-hydroxy-4-((E)-3-oxo-5-phenylpent-1-enyl)hexahydro-2H-cyclopenta[b]furan-2-one
• CAS NO: 933789-26-5
• Molecular Formula: C18H20O4
• Molecular Weight: 300.352
• Mol File: 933789-26-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 506°C at 760 mmHg
• Flash Point: 185.3°C
• Appearance: /
• Density: 1.282g/cm³
• Vapor Pressure: 4.65E-11mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: ENONE-L(CAS DataBase Reference)
• NIST Chemistry Reference: ENONE-L(933789-26-5)
• EPA Substance Registry System: ENONE-L(933789-26-5)

Safety Data

• Hazardous Substances Data: 933789-26-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H20O4/c19-13(7-6-12-4-2-1-3-5-12)8-9-14-15-10-18(21)22-17(15)11-16(14)20/h1-5,8-9,14-17,20H,6-7,10-11H2/b9-8+/t14-,15-,16-,17+/m1/s1

Upstream product

• 41162-19-0 dimethyl(2-oxo-4-phenylbutyl)phosphonate 
• 62961-72-2 Corey aldehyde 
• 87422-39-7 (3aR,6aS)-3,3-dichloro-3,3a,6,6a-tetrahydro-2H-cyclopenta[b]furan-2-one 
• 32233-40-2 (3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one 
• 542-92-7 cyclopenta-1,3-diene 
• 26054-46-6 (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one 
• 5307-99-3 (+/-)-7,7-dichlorobicyclo[3.2.0]hept-2-en-6-one 

Relevant articles and documents

Preparation method of bemeprost

The invention discloses a preparation method of bemeprost, which comprises the following steps: (1) in a first solvent, carrying out oxidation reaction on a compound 1 in an oxidation system to generate a compound 2; (2) in a second solvent, under the action of alkali, mixing the compound 2 with a compound 7 for reaction to generate a compound 3; (3) carrying out reduction reaction on the compound3 in a third solvent under the action of a first reducing agent to generate a compound 4; (4) in a fourth solvent, carrying out reduction reaction on the compound 4 under the action of a second reducing agent to generate a compound 5; and (5) in a fifth solvent, under the action of alkali, carrying out the following reaction on the compound 5 and the compound 8 to generate bemeprost of a compound6. According to the preparation method disclosed by the invention, the operation steps are remarkably simplified, the reaction conditions are mild, and the operation is simple and convenient; raw materials are cheap and easy to obtain, and cost is reduced; the product yield is high, and the method is suitable for industrial production.

Method for preparing prostaglandin F analogue

A method for preparing a prostaglandin F analogue represented by the following formula (I) is disclosed, wherein R1, and are as defined in the specification.