934-07-6

Basic information

• Product Name: methyl 5-bromo-1H-pyrrole-2-carboxylate
• Synonyms: 5-bromo-1H-Pyrrole-2-carboxylic acid methyl ester;1H-Pyrrole-2-carboxylic acid, 5-bromo-, methyl ester
• CAS NO: 934-07-6
• Molecular Formula: C₆H₆BrNO₂
• Molecular Weight: 204.022
• Mol File: 934-07-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 101-103 °C
• Boiling Point: 290.485°C at 760 mmHg
• Flash Point: 129.481°C
• Appearance: /
• Density: 1.675g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.18±0.50(Predicted)
• CAS DataBase Reference: methyl 5-bromo-1H-pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-bromo-1H-pyrrole-2-carboxylate(934-07-6)
• EPA Substance Registry System: methyl 5-bromo-1H-pyrrole-2-carboxylate(934-07-6)

Safety Data

• Hazardous Substances Data: 934-07-6(Hazardous Substances Data)

Usage

Uses

Methyl 5-Bromo-1H-pyrrole-2-carboxylate is a chemical reagent used in pharmaceutical synthesis.

InChI:InChI=1/C6H6BrNO2/c1-10-6(9)4-2-3-5(7)8-4/h2-3,8H,1H3

Upstream product

• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 117067-98-8 α-(dimethylamino)-α-(pyrrol-2-yl)acetonitrile 

Downstream Products

• 924708-81-6 methyl 5-bromo-1-(tert-butoxycarbonyl)-1H-pyrrole-2-carboxylate 
• 1000682-38-1 methyl 5-(4-tert-butylphenyl)-1H-pyrrole-2-carboxylate 
• 676501-89-6 methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-2-carboxylate 
• 1518920-07-4 6-bromo-3-(4-methoxyphenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one 
• 1518920-23-4 6-hydroxymethyl-3-(4-trifluoromethyl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one 
• 1518920-20-1 6-methyl-3-(4-trifluoromethylphenyl)-2H-pyrrol[1,2-a]pyrazin-1-one 
• 1518920-19-8 6-(4,5-dihydro-1H-imidazol-2-yl)-3-(4-trifluoromethyl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one 

Relevant articles and documents

Substrate Controlled Regioselective Bromination of Acylated Pyrroles Using Tetrabutylammonium Tribromide (TBABr3)

Electrophilic bromination of pyrroles bearing carbonyl substituents at C-2 typically results in a mixture of the 4- and 5-brominated species, generally favoring the 4-position. Herein, we describe a substrate-controlled regioselective bromination in which

Vanadate-dependent bromoperoxidases from Ascophyllum nodosum in the synthesis of brominated phenols and pyrroles

Bromoperoxidases from the brown alga Ascophyllum nodosum, abbreviated as VBrPO(AnI) and VBrPO(AnII), show 41% sequence homology and differ by a factor of two in the percentage of α-helical secondary structures. Protein monomers organize into homodimers for VBrPO(AnI) and hexamers for VBrPO(AnII). Bromoperoxidase II binds hydrogen peroxide and bromide by approximately one order of magnitude stronger than VBrPO(AnI). In oxidation catalysis, bromoperoxidases I and II turn over hydrogen peroxide and bromide similarly fast, yielding in morpholine-4-ethanesulfonic acid (MES)-buffered aqueous tert-butanol (pH 6.2) molecular bromine as reagent for electrophilic hydrocarbon bromination. Alternative compounds, such as tribromide and hypobromous acid are not sufficiently electrophilic for being directly involved in carbon-bromine bond formation. A decrease in electrophilicity from bromine via hypobromous acid to tribromide correlates in a frontier molecular orbital (FMO) analysis with larger energy gaps between the π-type HOMO of, for example, an alkene and the σ*Br,X-type LUMO of the bromination reagent. By using this approach, the reactivity of substrates and selectivity for carbon-bromine bond formation in reactions mediated by vanadate-dependent bromoperoxidases become predictable, as exemplified by the synthesis of bromopyrroles occurring naturally in marine sponges of the genera Agelas, Acanthella, and Axinella. The Royal Society of Chemistry.

Molecular cloning, structure, and reactivity of the second bromoperoxidase from Ascophyllum nodosum

The sequence of bromoperoxidase II from the brown alga Ascophyllum nodosum was determined from a full length cloned cDNA, obtained from a tandem mass spectrometry RT-PCR-approach. The clone encodes a protein composed of 641 amino-acids, which provides a mature 67.4 kDa-bromoperoxidase II-protein (620 amino-acids). Based on 43% sequence homology with the previously characterized bromoperoxidase I from A. nodosum, a tertiary structure was modeled for the bromoperoxidase II. The structural model was refined on the basis of results from gel filtration and vanadate-binding studies, showing that the bromoperoxidase II is a hexameric metalloprotein, which binds 0.5 equivalents of vanadate as cofactor per 67.4 kDa-subunit, for catalyzing oxidation of bromide by hydrogen peroxide in a bi-bi-ping-pong mechanism (kcat = 153 s-1, 22 °C, pH 5.9). Bromide thereby is converted into a bromoelectrophile of reactivity similar to molecular bromine, based on competition kinetic data on phenol bromination and correlation analysis. Reactivity provided by the bromoperoxidase II mimics biosynthesis of methyl 4-bromopyrrole-2-carboxylate, a natural product isolated from the marine sponge Axinella tenuidigitata.