934012-96-1

Basic information

• Product Name: 4-fluoro-2-vinylbenzonitrile
• Synonyms: 4-fluoro-2-vinylbenzonitrile
• CAS NO: 934012-96-1
• Molecular Weight: 147.152
• Mol File: 934012-96-1.mol

Chemical Properties

• CAS DataBase Reference: 4-fluoro-2-vinylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluoro-2-vinylbenzonitrile(934012-96-1)
• EPA Substance Registry System: 4-fluoro-2-vinylbenzonitrile(934012-96-1)

Safety Data

• Hazardous Substances Data: 934012-96-1(Hazardous Substances Data)

Upstream product

• 60702-69-4 2-chloro-4-fluorobenzonitrile 
• 94569-84-3 2-bromo-5-fluorobenzaldehyde 
• 828267-47-6 1-bromo-4-fluoro-2-vinylbenzene 

Relevant articles and documents

Unlocking Mizoroki–Heck-Type Reactions of Aryl Cyanides Using Transfer Hydrocyanation as a Turnover-Enabling Step

A new transfer hydrofunctionalization strategy to turnover H-MII-X complexes has enabled both intra- and intermolecular Mizoroki–Heck (MH)-type reactions of aryl cyanides that are challenging to realize under traditional, basic conditions. Initially, a cascade carbonickelation/MH reaction of 2-cyanostyrenes was achieved using a key alkyne transfer hydrocyanation step. Mechanistic experiments supported the proposed catalytic cycle, including the turnover-enabling transfer hydrocyanation step. The reactivity was then extended to the intermolecular MH reaction of benzonitriles and styrenes.

CN-assisted oxidative cyclization of cyano cinnamates and styrene derivatives: A facile entry to 3-substituted chiral phthalides

The asymmetric dihydroxylation (AD) of o-cyano cinnamates and styrene derivatives leads to efficient construction of chiral phthalide frameworks in high optical purities. This unique reaction is characterized by unusual synergism between CN and osmate groups resulting in rate enhancement of the AD process. The method is amply demonstrated by the synthesis and the structural/stereochemical assignment of the natural products.