934236-38-1Relevant academic research and scientific papers
One-pot fluorosulfurylation of Grignard reagents using sulfuryl fluoride
Lee, Cayo,Ball, Nicholas D.,Sammis, Glenn M.
, p. 14753 - 14756 (2019)
Herein, we report a new method for the one-pot syntheses of sulfonyl fluorides. Addition of an alkyl, aryl, or heteroaryl Grignard to a solution of sulfuryl fluoride at ambient temperature affords the desired sulfonyl fluorides in 18-78% yield. Furthermore, this method is applicable for in situ sequential reactions, whereby the Grignard reagent can be converted to the corresponding diarylsulfone, sulfonate ester, or sulfonamide in a one-pot process.
