934237-55-5Relevant academic research and scientific papers
Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis: A highly enantioselective route to β-amino acids
Ibrahem, Ismail,Rios, Ramon,Vesely, Jan,Zhao, Gui-Ling,Cordova, Armando
, p. 849 - 851 (2007)
The highly chemo- and enantioselective organocatalytic tandem reaction between N-protected hydroxyl amines and α,β-unsaturated aldehydes is presented; the reaction provides access to 5-hydroxyisoxazolidines and β-amino acids in high yields and with 90-99% ee. The Royal Society of Chemistry.
Catalytic enantioselective 5-hydroxyisoxazolidine synthesis: An asymmetric entry to β-amino acids
Ibrahem, Ismail,Rios, Ramon,Vesely, Jan,Zhao, Gui-Ling,Cordova, Armando
, p. 1153 - 1157 (2008/12/22)
The highly chemo- and enantioselective organocatalytic tandem reaction between N-carbamate-protected hydroxylamines and α,β-unsaturated aldehydes is presented. The reaction represents a unique entry for the asymmetric synthesis of 5-hydroxyisoxazolidines, oxazolidin-5-ones or γ-hydroxyamino alcohols in high yields and 90-99% ee. A procedure for the conversion of the oxazolidin-5-ones into the corresponding β-amino acids is also described. Georg Thieme Verlag Stuttgart.
