934237-57-7Relevant academic research and scientific papers
Catalytic enantioselective 5-hydroxyisoxazolidine synthesis: An asymmetric entry to β-amino acids
Ibrahem, Ismail,Rios, Ramon,Vesely, Jan,Zhao, Gui-Ling,Cordova, Armando
, p. 1153 - 1157 (2008)
The highly chemo- and enantioselective organocatalytic tandem reaction between N-carbamate-protected hydroxylamines and α,β-unsaturated aldehydes is presented. The reaction represents a unique entry for the asymmetric synthesis of 5-hydroxyisoxazolidines, oxazolidin-5-ones or γ-hydroxyamino alcohols in high yields and 90-99% ee. A procedure for the conversion of the oxazolidin-5-ones into the corresponding β-amino acids is also described. Georg Thieme Verlag Stuttgart.
Organocatalytic kinetic resolution of N-boc-isoxazolidine-5-ones
Straub, Matthew R.,Birman, Vladimir B.
supporting information, p. 984 - 988 (2021/02/06)
Easily accessible racemic N-Boc-isoxazolidine-5-ones undergo enantioselective alcoholysis promoted by double hydrogen bond donor amine organocatalysts, resulting in their effective kinetic resolution.
Organocatalytic asymmetric 5-hydroxyisoxazolidine synthesis: A highly enantioselective route to β-amino acids
Ibrahem, Ismail,Rios, Ramon,Vesely, Jan,Zhao, Gui-Ling,Cordova, Armando
, p. 849 - 851 (2007/10/03)
The highly chemo- and enantioselective organocatalytic tandem reaction between N-protected hydroxyl amines and α,β-unsaturated aldehydes is presented; the reaction provides access to 5-hydroxyisoxazolidines and β-amino acids in high yields and with 90-99% ee. The Royal Society of Chemistry.
