934246-94-3Relevant academic research and scientific papers
Efficient, enantioselective organocatalytic synthesis of trichostatin A
Zhang, Shilei,Duan, Wenhu,Wang, Wei
, p. 1228 - 1234 (2007/10/03)
An efficient, highly stereocontrolled total synthesis of trichostatin A (1) has been achieved in 9 steps with 17.4% overall yield and >99% optical purity from readily available achiral starting materials. The key features of this synthesis include the L-proline-promoted, highly enantioselective cross-aldol reaction as a crucial step for the construction of the C-6 chiral center and the minimization of racemization by final step oxidation of the OH group to a ketone at position 7.
