934264-58-1Relevant academic research and scientific papers
Synthesis of Vixotrigine, a Use-Dependent Sodium Channel Blocker. Part 1: Development of Bulk Supply Routes to Enable Proof of Concept
Giblin, Gerard,Heseltine, Adrian,Kiesman, William,Macpherson, David,Ramsden, James,Vadali, Ravi,Williams, Michael,Witty, David
, p. 2802 - 2813 (2020)
Two syntheses of vixotrigine are reported. Route 1, adapted from the medicinal chemistry route, enabled rapid delivery of drug substance for clinical development. Route 2, which was developed to address many of the limitations of Route 1, was used to manu
