93427-89-5Relevant academic research and scientific papers
Chlorosulfonic acid as a convenient electrophilic olefin cyclization agent
Linares-Palomino, Pablo J.,Salido, Sofía,Altarejos, Joaquín,Sánchez, Adolfo
, p. 6651 - 6655 (2003)
Among several sulfonic acids studied (MeSO3H, p-TsOH, H2SO4, ClSO3H, FSO3H), the scarcely used chlorosulfonic acid showed to be an efficient agent for electrophilic olefin cyclizations with internal nucleophilic termination, in a similar manner that is well-established with fluorosulfonic acid. Its availability, lower price and relatively lesser handling problems makes ClSO3H an advantageous cyclizing agent particularly for high-scale applications. The stereochemical outcome of these cyclizations has been rationalized.
