934280-95-2

Upstream product

• 893420-22-9 5-fluoro-4-(2-methyl-3-(propan-2-yl)-3H-imidazol-4-yl)pyrimidin-2-amine 
• 618-89-3 methyl 3-bromobenzoate 
• 862686-53-1 (2E)-3-(dimethylamino)-1-(1-isopropyl-2-methyl-1H-imidazol-5-yl) prop-2-en-1-one 
• 862685-76-5 (2Z)-3-(dimethylamino)-2-fluoro-1-(1-isopropyl-2-methyl-1H-imidazol-5-yl)prop-2-en-1-one 

Downstream Products

• 934280-89-4 3-{[5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl]amino}-N-(3-methoxypropyl)benzamide hydrochloride 

Relevant academic research and scientific papers

Use of Pyrimidine Derivatives in the Manufacture of a Medicament for Prevention and/or Treatment of Alzheimer's Disease

Pyrimidine derivatives of formula I, wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification, as a base or a pharmaceutically acceptable salt thereof in the manufacture of pharmaceutical compositions and in the treatment or prophylaxis of Alzheimer's Disease.

USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER’S DISEASE

The present invention relates to a new use of pyrimidine derivatives of formula I, as a free base or a pharmaceutically acceptable salt thereof in the manufacture of a medicament in the treatment and/or prophylaxis of Alzheimer's Disease: