93433-76-2

Usage

Preparation

Preparation by Fries rearrangement of 2,4-dimethylphenyl phenylacetate with aluminium chloride, ? without solvent for 15 min at 140–145° (85%) or for 1 h at 120° (56%); ? in refluxing chlorobenzene for 4 h (18%).

Upstream product

• 105-67-9 2,4-Xylenol 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 93433-73-9 phenyl-acetic acid-(2,4-dimethyl-phenyl ester) 

Downstream Products

• 133498-05-2 α-styryl 2-(4,6-dimethyl-1-hydroxyphenyl)ketone 
• 94093-97-7 2.4-Dibenzyl-6-phenaethyl-phenol 
• 1459243-95-8 C₁₇H₁₄O₂ 
• 1459244-03-1 C₁₇H₁₅F₃O₄S 
• 21553-47-9 2-Methoxy-3,5-dimethylbenzoic acid 
• 6245-04-1 3,5-dimethylsalicylic acid 
• 93903-29-8 2.4-Dimethyl-6-phenethyl-2-acetoxy-cyclohexadien-(3.5)-on-⁽¹⁾ 
• 95279-82-6 2-Methoxy-3,5-dimethyl-benzil 
• 103246-79-3 1-amino-2,3-dihydro-4,6-dimethyl-7-hydroxy-2-phenyl-1H-indene 
• 103246-59-9 4,6-dimethyl-7-hydroxy-2-phenyl-1-indanone 
• 103234-09-9 4,6-dimethyl-7-hydroxy-2-phenyl-1-indanone 

Relevant academic research and scientific papers

Synthesis of 7-hydroxy-6H-naphtho[2,3-c]coumarinviaa TsOH-mediated tandem reaction

A concise and efficient method for the synthesis of 7-hydroxy-6H-naphtho[2,3-c]coumarin using available 1-(2-hydroxyphenyl)-2-phenylethanone and Meldrum's acid has been developed. This transformation involved a tandem aldol reaction/lactonization/Friedel-Crafts reaction to form a lactone ring and a benzene ring. It showed high atom economy with water and acetone as the byproducts. Mechanism studies demonstrated two roles of Meldrum's acid: (i) as the reagent for the tandem reaction, and (ii) as the catalyst for the Friedel-Crafts reaction. Moreover, the hydroxyl group of 7-hydroxy-6H-naphtho[2,3-c]coumarin was further functionalized efficiently by arylethynyl, aryl, and cyano groups to furnish D-π-A compounds with excellent fluorescence emissions (ΦF= 0.14-0.78).

3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators

Following the recent identification of the naturally occurring 3-ylidene-4,5-dihydrophthalide ligustilide and its oxidation product dehydroligustilide as novel TRPA1 modulators, a series of seventeen 3-ylidenephthalides was synthesized and tested on TRPA1 and TRPM8 channels. Most of these compounds acted as strong modulators of the two channel types with EC50 and/or IC50 values distinctly lower than those of the reference compounds.

Novel Cerebroprotective Agents with Central Nervous System Stimulating Activity. 1. Synthesis and Pharmacology of 1-Amino-7-hydroxyindan Derivatives

To developed a novel cerebroprotective agent with central nervous system (CNS) stimulating activity, a series of 1-amino-7-hydroxyindan derivatives was synthesized, and their effects on the survival time of mice under hypoxic conditions were tested.CNS-stimulating activity was also evaluated by examining the promotional effect on the recovery from cerebral concussion induced coma in mice.Several compounds prolonged the survival time of mice in hypoxic conditions at a dose of 30 mg/kg (sc or ip) and 100 mg/kg (po).They also exhibited the promotional effects on recovery from coma at a dose of 100 mg/kg po.The three most potent compounds in both tests, 1-amino-7-hydroxy-6-(1-methylpropyl)indan (20), 1-amino-7-hydroxy-4,6-dimethyl-2-phenylindan (30), and 1-amino-7-hydroxy,2,2,4,6-tetramethylindan (35) were selected for further investigations.Structure-activity relationships were also discussed.