93434-80-1

Upstream product

• 100-44-7 benzyl chloride 
• 5000-44-2 1-phenylsulfonyl-2-propanone 
• 107402-99-3 2,5-dimethyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole 
• 119017-23-1 2-methyl-3-phenyl-4-phenylsulphonyl-5-styryl-2,3-dihydroisoxazole 
• 117012-21-2 C₁₇H₁₈O₂S₂ 
• 31984-10-8 1-bromo-4-phenylbutan-2-one 
• 873-55-2 sodium benzenesulfonate 
• 20845-80-1 1-chloro-4-phenylbutan-2-one 
• 108-98-5 thiophenol 
• 117037-41-9 (2-Methylsulfanyl-prop-2-ene-1-sulfonyl)-benzene 
• 2525-40-8 prop-2-ynylsulfonylbenzene 
• 113549-17-0 Methanesulfonic acid 2-(4-benzenesulfonyl-2-methyl-3-phenyl-2,3-dihydro-isoxazol-5-yl)-1-phenyl-ethyl ester 
• 113549-31-8 5-(2-hydroxyphenethyl)-2-methyl-3-phenyl-4-phenylsulphonyl-2,3-dihydroisoxazole 

Downstream Products

• 1083068-79-4 C₂₃H₂₉NO₅S 
• 51114-72-8 2-(phenylsulfonyl)-3,4-dihydronaphthalen-1(2H)-one 
• 117012-44-9 1-Benzenesulfonyl-1-diazo-4-phenyl-butan-2-one 

Relevant academic research and scientific papers

Mukaiyama reagent-promoted metal-free preparation of alkynyl sulfones and phosphonates under mild conditions

An efficient and mild route for the formation sulfur or phosphor-substituted alkynes was herein demonstrated. The Mukaiyama reagent-mediated transformation started from easily-accessible substrates without carbon-carbon triple bonds, and the reaction proceeded under mild conditions (room temperature) in a one-pot manner, requiring for no transition metal-catalysts. The practical protocol featured for good functional groups tolerance (up to 41 examples) and high efficiency (up to 91% yields) towards alkynyl sulfones and alkynyl phosphonates at low cost.

Studies on the chemistry and reactivity of α-substituted ketones in isonitrile-based multicomponent reactions

(Chemical Equation Presented) Using the Passerini and Ugi reactions as representative tests, the utility of several α-substituted ketones R-CO-CH2-X (X = sulfonyloxy, acyloxy, azido, halo, hydroxy, and sulfonyl) in isonitrile-based multicompone

ALKYATION STUDIES OF 5-EXO-METHYLENE SUBSTITUTED ISOXAZOLIDINES

1,3-Dipolar cycloaddition of nitrones to phenylsulphonylallene gives in high yield and with complete regiospecificity 5-methyleneisoxazolidines.These on treatment with base and subsequent reaction with electrophiles afford both α- and γ-substituted products.With methyl iodide as the electrophile, only the α-methylated product was isolated.In contrast, reaction of the 5-exo-methylene-4-phenylsulphonylisoxazolidine with allyl bromide afforded the γ-allyated product.Formation of this was shown to be via direct γ-attack, rather than by α-attack, followed by a 3,3-sigmatropic rearrangement.Further studies show that the product ratio is controlled by a sensitive interplay between thermodynamic and steric factors and is very dependent on the nature of the electrophile used.

CYCLOPENTANATION WITH β-METHYLTHIO-ALLYL PHENYL SULFONE

The allylic thiosulfones 2 resulting from the addition of thiols to propargylic sulfone 1 have been used to convert enones into diketo-sulfones which then led to bicyclo alkanediones by either tris-anionization then cupric oxidation or treatment with rhodium acetate of the corresponding diazoketo-sulfone.