93434-89-0

Upstream product

• 608-25-3 2-methylbenzene-1,3-diol 
• 104-47-2 p-methoxybenzylnitrile 
• 104-01-8 4-Methoxyphenylacetic acid 

Downstream Products

• 39604-65-4 4,4'-dimethoxy-2-hydroxy-3-methyldeoxybenzoin 
• 116718-51-5 7-hydroxy-3-(4-methoxyphenyl)-8-methyl-4H-chromen-4-one 
• 1571900-02-1 7-methoxy-3-(4-methoxyphenyl)-8-methyl-2-phenyl-4H-chromen-4-one 
• 1571900-03-2 7-methoxy-2,3-bis(4-methoxyphenyl)-8-methyl-4H-chromen-4-one 
• 1571900-05-4 2-(3,4-dimethoxyphenyl)-7-methoxy-3-(4-methoxyphenyl)-8-methyl-4H-chromen-4-one 
• 1571899-92-7 7-methoxy-3-(4-methoxyphenyl)-flavone-8-acetic acid 
• 1571899-93-8 7-methoxy-3-(4-methoxyphenyl)-4'-methoxyflavone-8-acetic acid 
• 1571899-94-9 7-methoxy-3-(4-methoxyphenyl)-3',4'-dimethoxyflavone-8-acetic acid 
• 262600-98-6 7-acetoxy-8-<2,2-bis-(ethoxycarbonyl)ethyl>-3-(4-methoxyphenyl)-4H-chromen-4-one 
• 262600-99-7 8-(2-carboxyethyl)-7-hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one 
• 262600-97-5 8-bromomethyl-7-acetoxy-3-(4-methoxyphenyl)-4H-chromen-4-one 
• 262600-96-4 7-acetoxy-3-(4-methoxyphenyl)-8-methyl-4H-chromen-4-one 
• 288266-76-2 7-acetoxy-3-(4-acetoxy-phenyl)-8-methyl-chromen-4-one 
• 860369-03-5 4',7-dimethoxy-8-methylisoflavone 

Relevant academic research and scientific papers

Synthesis, selective cytotoxicities and probable mechanism of action of 7-methoxy-3-arylflavone-8-acetic acids

Thirteen new analogues of flavone-8-acetic acid, that is, compounds 10a-m bearing a methoxy group at the 7-position and diverse subsitiuents on the benzene ring at the 2- and 3-positions of flavone nucleus, were synthesized and evaluated for their direct

The preparation of new isoflavones

The synthesis of ten new isoflavones in good yield is described. The method, involving intermediate 2-hydroxybenzyl ketones, did not require protection of the hydroxyl groups of the starting polyphenols.

Synthesis of haptens and conjugates for ELISAs of phytoestrogens. Development of the immunological tests

Seven carboxylic acid haptens of isoflavonoids were synthesized, with the spacer arm on the oxygen atom at the C7 position for one series, with formononetin, daidzein, equol, biochanin A, and genistein, and at the C8 position for a second series, with only formononetin and daidzein. The different haptens were coupled to bovine serum albumin (BSA) and to swine thyroglobulin (Thyr). Polyclonal antibodies were generated against the BSA conjugates. Enzyme-linked immunosorbent assays (ELISAs) were developed based on competition between free phytoestrogens and the Thyr-hapten conjugates for specific antibodies. IC50 values of the standard curves ranged between 0.8 and 20 ng/mL that is, 0.3 and 9.2 pmol/well. The antibodies obtained should be useful for assays in vegetable matter as well as in biological fluids after a separation step. These ELISAs should be valuable also in the food industry to control phytoestrogen concentrations prior to and after processing.