934371-48-9

Basic information

• Product Name: (+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester
• Synonyms: (+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester
• CAS NO: 934371-48-9
• Molecular Weight: 320.389
• Mol File: 934371-48-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: >47°C (dec.)
• Boiling Point: 518.0±60.0 °C(Predicted)
• Density: 1.22±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester(934371-48-9)
• EPA Substance Registry System: (+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester(934371-48-9)

Safety Data

• Hazardous Substances Data: 934371-48-9(Hazardous Substances Data)

Usage

Uses

(S)-Carbidopa Methyl Ester N-cyclohexylideneis an impurity of Carbidopa (C175915), a prodrug inhibitor of aromatic amino acid decarboxylase.

Upstream product

• 18181-08-3 L-methyldopa methyl ester 
• 185-80-8 1-oxa-2-azaspiro[2.5]octane 

Downstream Products

• 302-53-4 S(-)-carbidopa 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF CARBIDOPA

The invention relates to a process for the preparation of (-) - (L) -3- (3,4-dihydroxyphenyl) -2-hydrazino-2 -methyl propionic acid (carbidopa) of the formula (II) by using 3, 3 -pentamethylene oxaziridine of the formula (IV), which comprises reacting L-α-methyldopa methyl ester of the formula (III) with 3,3-penta- methylene oxaziridine of the formula (IV), isolating the thus-obtained (+) - (L) -2- (N' - cyclohexylidene-hydrazino) -3- (3 , 4-dihydroxy phenyl) -2 -methyl propionic acid methyl ester of the formula (I) (I) and subjecting it to hydrolysis with an acid. (+) - (L) -2- (N' -cyclohexylidene-hydrazino) -3-(3,4-dihydroxyphenyl) -2-methyl propionic acid methyl ester of the formula (I) is a new intermediate . (-) - (L)-3-(3,4-dihydroxyphenyl) -2-hydrazino-2- methyl propionic acid (carbidopa) of the formula (XI) thus obtained is a valuable therapeutic active ingredient having the international non-proprietary name carbidopa.