934394-41-9

Basic information

• Product Name: [5-benzylamino-7-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-1-cyclopropyl-6,8-difluoro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-carbamic acid tert-butyl ester
• Synonyms: [5-benzylamino-7-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-1-cyclopropyl-6,8-difluoro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-carbamic acid tert-butyl ester
• CAS NO: 934394-41-9
• Molecular Weight: 642.703
• Mol File: 934394-41-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [5-benzylamino-7-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-1-cyclopropyl-6,8-difluoro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [5-benzylamino-7-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-1-cyclopropyl-6,8-difluoro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-carbamic acid tert-butyl ester(934394-41-9)
• EPA Substance Registry System: [5-benzylamino-7-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-1-cyclopropyl-6,8-difluoro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-carbamic acid tert-butyl ester(934394-41-9)

Safety Data

• Hazardous Substances Data: 934394-41-9(Hazardous Substances Data)

Upstream product

• 4522-93-4 ethyl pentafluorobenzoate 
• 602-94-8 Pentafluorobenzoic acid 
• 870-46-2 t-butoxycarbonylhydrazine 
• 172414-99-2 4-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-2,3,5,6-tetrafluoro-benzoic acid ethyl ester 
• 934394-40-8 [7-(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-1-cyclopropyl-5,6,8-trifluoro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-carbamic acid tert-butyl ester 
• 100-46-9 benzylamine 

Relevant articles and documents

Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors

A series of 3-aminoquinazolinediones was synthesized and evaluated for its antibacterial and DNA gyrase activity. The SAR around the quinazolinedione core was explored and the optimal substitutions were combined to give two compounds, 2r and 2s, with exceptional enzyme potency (IC50 = 0.2 μM) and activity against Gram-positive organisms (MIC's = 0.015-0.06 μ g/mL).