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Usage

Uses

Used in Pharmaceutical Industry:
Kibdelone C is used as an anticancer agent for its potent and selective cytotoxicity against various human tumor cell lines. Its low nanomolar effectiveness makes it a promising candidate for cancer treatment.
Used in Research Applications:
Kibdelone C is used as a research tool to study the mode of action and pharmacology of the kibdelones, as well as their potential applications in cancer therapy. Its unique ability to disrupt the actin cytoskeleton without directly binding actin or affecting its polymerization in vitro provides valuable insights into the development of novel cancer treatments.

Upstream product

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• 1311379-47-1 C₈H₁₁IO₅ 
• 1311379-42-6 C₁₆H₃₀O₄Si 
• 1311379-23-3 methyl (3aR,6S,7aS)-6-hydroxy-5-iodo-2,2-dimethyl-3a,6,7,7a-tetrahydrobenzo-[d][1,3]dioxole-4-carboxylate 
• 1311379-34-6 C₃₄H₃₈ClNO₁₁ 
• 1311379-36-8 C₃₃H₃₄ClNO₁₀ 
• 1311379-25-5 C₁₇H₂₂O₄ 
• 1311379-39-1 kibdelone C methyl ether 
• 1311402-02-4 C₁₁H₁₃BrO₅ 
• 1147862-00-7 1,5-bis((tert-butyldimethylsilyl)oxy)cyclohexa-1,4-diene 
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Relevant academic research and scientific papers

Synthesis and Biological Evaluation of Kibdelone C and Its Simplified Derivatives

Poylcyclic tetrahydroxanthones comprise a large class of cytototoxic natural products. No mechanism of action has been described for any member of the family. We report the synthesis of kibdelone C and several simplified analogs. Both enantiomers of kibdeleone C show low nanomolar cytotoxicity toward multiple human cancer cell lines. Moreover, several simplified derivatives with improved chemical stability display higher activity than the natural product itself. In vitro studies rule out interaction with DNA or inhibition of topoisomerase, both of which are common modes of action for polycyclic aromatic compounds. However, celluar studies reveal that kibdelone C and its simplified derivatives disrupt the actin cytoseketon without directly binding actin or affecting its polymerization in vitro.

Total synthesis and absolute stereochemical assignment of kibdelone C

Kibdelones are hexacyclic tetrahydroxanthones and potent anticancer agents isolated from an Australian microbe. Herein, we describe the synthesis of a chiral, nonracemic iodocyclohexene carboxylate EF ring fragment of the kibdelones employing an intramolecular iodo halo-Michael aldol reaction and its merger with an ABCD ring fragment to afford the congener kibdelone C.