934497-49-1

Downstream Products

• 1392445-48-5 (S,5E,9Z)-2-((R)-4-((tert-butyldimethylsilyl)oxy)butan-2-yl)-11-((4-methoxybenzyl)oxy)-2,5,9-trimethylundeca-5,9-dien-1-ol 
• 1392445-52-1 (1S,4E,8Z,12R,14R)-15-iodo-1,4,8,14-tetramethyl-10-oxobicyclo[9.3.1]pentadeca-4,8,11⁽¹⁵⁾-trien-12-yl-4-nitrobenzoate 
• 1392445-42-9 (Z)-1-methoxy-4-((3-methyloct-2-en-6-ynyloxy)methyl)benzene 
• 1392445-41-8 (Z)-1-methoxy-4-((3-methylhept-2-en-6-ynyloxy)methyl)benzene 
• 1392445-47-4 (6S,7R)-6-((3E,7Z)-9-(4-methoxybenzyloxy)-3,7-dimethylnona-3,7-dienyl)-2,2,3,3,6,7,11,11,12,12-decamethyl-4,10-dioxa-3,11-disilatridecane 
• 1392445-39-4 1-(((2Z,6E)-7-iodo-3-methylocta-2,6-dienyloxy)methyl)-4-methoxybenzene 
• 1392445-43-0 ((2E,6Z)-8-(4-methoxybenzyloxy)-6-methylocta-2,6-dien-2-yl)dimethyl(phenyl)silane 

Relevant academic research and scientific papers

Total synthesis of the potent antitumor macrolides pladienolide B and D

Getting cross: The total syntheses of two pladienolides (see picture), which have prominent antitumor activity based on a unique mechanism of action, have been accomplished, and their absolute configurations were verified. The 12-membered aliphatic macrolide structure was formed by ring-closing metathesis, and the side-chain moiety was coupled to the macrolide by Julia-Kocienski olefination or cross-metathesis. (Chemical Equation Presented).

Process for total synthesis of pladienolide B and pladienolide D

[Problems to be Solved] To provide an effective process for total synthesis of pladienolide B and pladienolide D having excellent anti-tumor activity and to provide useful intermediates in the above-described process. [Measure for Solving the Problem] A process for producing a compound represented by Formula (11): wherein P1, P7, P8, P9 and R1 are the same as defined below, characterized by including reacting a compound represented by Formula (12): wherein P7 means a hydrogen atom or a protecting group for hydroxy group; R1 means a hydrogen atom or a hydroxy group, with a compound represented by Formula (13): wherein P1 means a hydrogen atom or a protecting group for hydroxy group; P8 means a hydrogen atom, an acetyl group or a protecting group for hydroxy group; P9 means a hydrogen atom or a protecting group for hydroxy group; or P8 and P9 may form together a group represented by a formula: wherein R5 means a phenyl group which may have a substituent, in the presence of a catalyst.